(Q33813567)

29 July 2017

title

Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease (English)

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29 July 2017

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Katherine J Franz

2

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author name string

Lissette R Perez

series ordinal

1

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29 July 2017

language of work or name

English

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publication date

17 December 2009

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29 July 2017

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29 July 2017

volume

39

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29 July 2017

issue

9

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29 July 2017

page(s)

2177-2187

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Metal trafficking: from maintaining the metal homeostasis to future drug design

29 July 2017

cites work

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

4 July 2018

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4 July 2018

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Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.

4 July 2018

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Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents

4 July 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

4 July 2018

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4 July 2018

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Metal complexes as artificial proteases: toward catalytic drugs

4 July 2018

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Antiparkinson prodrugs

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4 July 2018

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A Novel iron-chelating derivative of the neuroprotective peptide NAPVSIPQ shows superior antioxidant and antineurodegenerative capabilities

4 July 2018

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4 July 2018

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Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

4 July 2018

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Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

4 July 2018

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Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases.

4 July 2018

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Copper and iron disorders of the brain

4 July 2018

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The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.

4 July 2018

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Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

4 July 2018

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4 July 2018

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Oxidative stress and neurodegeneration: where are we now?

4 July 2018

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Mammalian zinc transport, trafficking, and signals

4 July 2018

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

4 July 2018

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Design of targeting ligands in medicinal inorganic chemistry

4 July 2018

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The evolution of iron chelators for the treatment of iron overload disease and cancer.

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

4 July 2018

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Metals, toxicity and oxidative stress

4 July 2018

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4 July 2018

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Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

4 July 2018

1 reference

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Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

4 July 2018

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Iron, brain ageing and neurodegenerative disorders

4 July 2018

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Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases

4 July 2018

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The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

The metallobiology of Alzheimer's disease

4 July 2018

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Iron chelator research: past, present, and future

4 July 2018

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Iron overload, oxidative stress, and axonal dystrophy in brain disorders

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

Structure-activity investigation of the inhibition of 3-hydroxypyridin-4-ones on mammalian tyrosine hydroxylase

4 July 2018

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Protection against oxidative damage by iron chelators: effect of lipophilic analogues and prodrugs of N,N'-bis(3,4,5-trimethoxybenzyl)ethylenediamine- N,N'-diacetic acid (OR10141)

4 July 2018

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Iron and activated oxygen species in biology: the basic chemistry

4 July 2018

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Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: the role of ferritin

4 July 2018

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Neuroprotection by the metabolic antioxidant alpha-lipoic acid

4 July 2018

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4 July 2018

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N,N'-bis-(3,4,5-trimethoxybenzyl) ethylenediamine N,N'-diacetic acid as a new iron chelator with potential medicinal applications against oxidative stress

4 July 2018

1 reference

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4 July 2018

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Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo

4 July 2018

1 reference

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Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease

4 July 2018

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30 October 2018

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Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

30 October 2018

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Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

30 October 2018

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Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress

30 October 2018

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Cleavage agents for soluble oligomers of amyloid beta peptides.

30 October 2018

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Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy

30 October 2018

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30 October 2018

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In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model

30 October 2018

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Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance

30 October 2018

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L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

30 October 2018

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Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

30 October 2018

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Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

30 October 2018

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Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

30 October 2018

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Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases

30 October 2018

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Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.

30 October 2018

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Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes

30 October 2018

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Neurodegenerative diseases and oxidative stress

30 October 2018

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Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.

30 October 2018

1 reference

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Synthesis and evaluation of iron chelators with masked hydrophilic moieties

30 October 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

30 October 2018

1 reference

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Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860397

EDTA bis-(ethyl phenylalaninate): a novel transition metal-ion chelating hydroxyl radical scavenger with a potential anti-inflammatory role

30 October 2018

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30 October 2018

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3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity

30 October 2018

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12 December 2020

Superactive lipophilic peptides discriminate multiple vasoactive intestinal peptide receptors

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12 December 2020

A Pro-Chelator Triggered by Hydrogen Peroxide Inhibits Iron-Promoted Hydroxyl Radical Formation

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12 December 2020

New drug delivery strategies for improved Parkinson's disease therapy

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12 December 2020

Caged-Iron Chelators a Novel Approach towards Protecting Skin Cells against UVA-Induced Necrotic Cell Death

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12 December 2020

Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress

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12 December 2020

Identifiers

DOI

10.1039/B919237A

1 reference

29 July 2017

1 reference

29 July 2017

1 reference