(Q33882182)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

review article

1 reference

title

Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

3

Nancy J Rothwell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

Andrew D Greenhalgh

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

James P Galea

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

language of work or name

English

0 references

publication date

27 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

29 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

681-695

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521135%20AND%20SRC:MED&resulttype=core&format=json

Stroke research priorities for the next decade--A representative view of the European scientific community.

29 January 2020

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21 January 2018

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1,026 experimental treatments in acute stroke

21 January 2018

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A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

21 January 2018

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How can we improve the pre-clinical development of drugs for stroke?

21 January 2018

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Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

21 January 2018

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Pharmacokinetic(s) matters: stroke treatment et cetera

21 January 2018

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Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials

21 January 2018

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Interleukin-1 and neuronal injury

21 January 2018

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Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

21 January 2018

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An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

21 January 2018

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

21 January 2018

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Emergency medical services-based community stroke education: pilot results from a novel approach

21 January 2018

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Neuroprotective role of lactate after cerebral ischemia

21 January 2018

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Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

21 January 2018

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Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

21 January 2018

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Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

21 January 2018

1 reference

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Systemic infection, inflammation and acute ischemic stroke.

21 January 2018

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Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans

21 January 2018

1 reference

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Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial

21 January 2018

1 reference

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PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism.

21 January 2018

1 reference

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Pharmacokinetics of anakinra in subjects with different levels of renal function

21 January 2018

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Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

21 January 2018

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Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

21 January 2018

1 reference

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Acute ischaemic stroke and infection: recent and emerging concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Drug absorption may be delayed after stroke: results of the paracetamol absorption test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Intranasal delivery to the central nervous system: mechanisms and experimental considerations

21 January 2018

1 reference

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Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke

21 January 2018

1 reference

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Comparative pathology of the nasal mucosa in laboratory animals exposed to inhaled irritants

21 January 2018

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Modelling of the blood-brain barrier in drug discovery and development.

21 January 2018

1 reference

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Astrocyte-endothelial interactions at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Structure and function of the blood-brain barrier

21 January 2018

1 reference

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The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

1 reference

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In silico prediction of blood–brain barrier permeation

21 January 2018

1 reference

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

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Drug resistance in brain diseases and the role of drug efflux transporters.

21 January 2018

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Implications of ATP-binding cassette transporters for brain pharmacotherapies

21 January 2018

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Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia.

21 January 2018

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ABCC1: a gateway for pharmacological compounds to the ischaemic brain.

21 January 2018

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Brain ischemia and reperfusion: molecular mechanisms of neuronal injury

21 January 2018

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Applicability of biomarkers in ischemic stroke.

21 January 2018

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Tissue plasminogen activator for acute ischemic stroke

21 January 2018

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Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

21 January 2018

1 reference

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Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke

21 January 2018

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Severe blood-brain barrier disruption and surrounding tissue injury

21 January 2018

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Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator

21 January 2018

1 reference

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Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation

21 January 2018

1 reference

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Post-ischemic blood-brain barrier leakage in rats: one-week follow-up by MRI.

21 January 2018

1 reference

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The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Application of microdialysis in pharmacokinetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Methodological aspects on microdialysis protein sampling and quantification in biological fluids: an in vitro study on human ventricular CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

A new model for prediction of drug distribution in tumor and normal tissues: pharmacokinetics of temozolomide in glioma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Physical interactions of static magnetic fields with living tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Magnetic resonance spectroscopy: current and future applications in psychiatric research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

WHO cytokine standardization: facilitating the development of cytokines in research, diagnosis and as therapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

The effects of anticoagulation and processing on assays of IL-6, sIL-6R, sIL-2R and soluble transferrin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Tumor necrosis factor measurement and use of different anticoagulants: possible interference in plasma samples and supernatants from endotoxin-stimulated monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Safety of extended treatment with anakinra in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Modelling during drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Whole body pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

The use of population pharmacokinetics in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Methodological issues in pharmacokinetic-pharmacodynamic modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Clinical trial simulation: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Pharmacometrics: a multidisciplinary field to facilitate critical thinking in drug development and translational research settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259

Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.570259