(Q33935822)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

4

Brian Giunta

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

5

Jared Ehrhart

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

12

Jun Tan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2

Demian Obregon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

11

Terrence Town

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

7

Takashi Mori

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Yuyan Zhu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Huayan Hou

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Frank Fernandez

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Yangbing Zhao

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Dave Morgan

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

publication date

1 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cellular and Molecular Medicine

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

327-338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

Alternative Abeta immunotherapy approaches for Alzheimer's disease

12 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Blood protein signature for the early diagnosis of Alzheimer disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Inflammaging as a prodrome to Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Studies on brain volume, Alzheimer-related proteins and cytokines in mice with chronic overexpression of IL-1 receptor antagonist

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Notch signaling modulates the activation of microglial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Genetic mouse models of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891003

Computational insights into aspartyl protease activity of presenilin 1 (PS1) generating Alzheimer amyloid beta-peptides (Abeta40 and Abeta42).

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Abeta40 inhibits amyloid deposition in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00962.X

TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19900216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19900216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19900216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1582-4934.2009.00962.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19900216%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference