(Q33938090)

30 July 2017

1 reference

title

Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4. (English)

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30 July 2017

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Friedberg EC

1

1 reference

PubMed ID

10844240

30 July 2017

Meira LB

series ordinal

2

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PubMed ID

10844240

30 July 2017

language of work or name

English

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publication date

1 May 2000

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30 July 2017

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30 July 2017

459

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30 July 2017

243-274

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30 July 2017

4

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Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.B.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Characterization of defective nucleotide excision repair in XPC mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Genetic interaction between HAP1/REF-1 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Female embryonic lethality in mice nullizygous for both Msh2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

No female embryonic lethality in mice nullizygous for Msh2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Meiotic pachytene arrest in MLH1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Involvement of Brca2 in DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Brca2 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

INK4d-deficient mice are fertile despite testicular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Genomic instability in Gadd45a-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2800%2900006-9

7 January 2021

10.1016/S0921-8777(00)00006-9

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10844240