(Q33963735)

30 July 2017

title

Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery? (English)

1 reference

functional magnetic resonance imaging

30 July 2017

1 reference

1 reference

1

David Borsook

1 reference

30 July 2017

Richard Hargreaves

2

1 reference

30 July 2017

Lino Becerra

series ordinal

3

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 June 2011

1 reference

Expert Opinion on Drug Discovery

30 July 2017

published in

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30 July 2017

volume

6

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30 July 2017

issue

6

1 reference

30 July 2017

page(s)

597-617

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Use of Florbetapir-PET for Imaging β-Amyloid Pathology

30 July 2017

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5 July 2018

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Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Alterations in brain structure and functional connectivity in prescription opioid-dependent patients

5 July 2018

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Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain

5 July 2018

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5 July 2018

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The use of imaging in preclinical drug development

5 July 2018

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Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development

5 July 2018

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Wake and sleep EEG provide biomarkers in depression

5 July 2018

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Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort

5 July 2018

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5 July 2018

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The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population.

5 July 2018

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5 July 2018

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Excitatory neurotransmitters in brain regions in interictal migraine patients

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study

5 July 2018

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5 July 2018

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Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI).

5 July 2018

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Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures.

5 July 2018

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5 July 2018

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Voxel-wise assessment of progression of regional brain atrophy in relapsing-remitting multiple sclerosis

5 July 2018

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MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths

5 July 2018

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Sodium MR imaging detection of mild Alzheimer disease: preliminary study

5 July 2018

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The rising prevalence of chronic low back pain

5 July 2018

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5 July 2018

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5 July 2018

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Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

5 July 2018

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5 July 2018

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Degradation of association and projection white matter systems in alcoholism detected with quantitative fiber tracking

5 July 2018

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Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis

5 July 2018

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Risk in CNS drug discovery: focus on treatment of Alzheimer's disease

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The role of imaging in proof of concept for CNS drug discovery and development

5 July 2018

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5 July 2018

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5 July 2018

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Imaging structural and functional connectivity: towards a unified definition of human brain organization?

5 July 2018

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A 'BOLD' experiment in defining the utility of fMRI in drug development

5 July 2018

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Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements

5 July 2018

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What we can do and what we cannot do with fMRI

5 July 2018

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Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies

5 July 2018

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A pivotal moment in 50 years of headache history: the first American Migraine Study

5 July 2018

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White matter pathology isolates the hippocampal formation in Alzheimer's disease

5 July 2018

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Chronic pain may change the structure of the brain

5 July 2018

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Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings.

5 July 2018

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Magnetic resonance methods and applications in pharmaceutical research

5 July 2018

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The Role of Molecular Imaging in Drug Discovery and Development

5 July 2018

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Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review

5 July 2018

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Selective changes of resting-state networks in individuals at risk for Alzheimer's disease

5 July 2018

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Synchronized delta oscillations correlate with the resting-state functional MRI signal

5 July 2018

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Strategic approach to fit-for-purpose biomarkers in drug development

5 July 2018

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The application of graph theoretical analysis to complex networks in the brain

5 July 2018

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Cortical and subcortical plasticity in the brains of humans, primates, and rats after damage to sensory afferents in the dorsal columns of the spinal cord

5 July 2018

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Diffusion Tensor Imaging of the Brain

5 July 2018

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Promises of biomarkers in drug development--a reality check

5 July 2018

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Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic

5 July 2018

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Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

5 July 2018

1 reference

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Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?

5 July 2018

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Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers

5 July 2018

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Animal models of neurodegenerative disease: insights from in vivo imaging studies

5 July 2018

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The epidemiology of narcolepsy.

5 July 2018

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The 2006 Henry N. Wagner Lecture: Of mice and men (and positrons)--advances in PET imaging technology.

5 July 2018

1 reference

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Consistent resting-state networks across healthy subjects

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Applications of fMRI in translational medicine and clinical practice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Arterial spin labeling: benefits and pitfalls of high magnetic field

5 July 2018

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A role for fMRI in optimizing CNS drug development

5 July 2018

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Adaptation: from single cells to BOLD signals

5 July 2018

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Alzheimer's disease and P300: review and evaluation of task and modality

5 July 2018

1 reference

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Positron Emission Tomography: applications in drug discovery and drug development

5 July 2018

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Prevalence and treatment of mental disorders, 1990 to 2003

5 July 2018

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Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Amygdala and hippocampus volumes in pediatric major depression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Chronic back pain is associated with decreased prefrontal and thalamic gray matter density.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Integrated technology for evaluation of brain function and neural plasticity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Localized in vivo 13C NMR spectroscopy of the brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Alzheimer Disease in the US Population

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Clinical biomarkers in drug discovery and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Making better drugs: Decision gates in non-clinical drug development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Biomarkers for the effects of benzodiazepines in healthy volunteers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Functional connectivity in the resting brain: a network analysis of the default mode hypothesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Prevalence of autism in a US metropolitan area

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

The prevalence and burden of arthritis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Biomarkers for the effects of antipsychotic drugs in healthy volunteers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Optimizing the use of biomarkers, surrogate endpoints, and clinical endpoints for more efficient drug development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

The prevalence and characteristics of fibromyalgia in the general population.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Brain magnetic resonance imaging with contrast dependent on blood oxygenation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Functional mapping of the human visual cortex by magnetic resonance imaging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Quantification of cerebral blood flow as biomarker of drug effect: arterial spin labeling phMRI after a single dose of oral citalopram

5 July 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Using the BOLD MR signal to differentiate the stereoisomers of ketamine in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naïve rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Pharmacological modulation of functional connectivity: the correlation structure underlying the phMRI response to d-amphetamine modified by selective dopamine D3 receptor antagonist SB277011A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Why University-Industry Partnerships Matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Collaborations among academia, government, and industry in the diagnostics space: barriers and some ideas for solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Computational fluid dynamics simulation of transcatheter aortic valve degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Prevalence of narcolepsy symptomatology and diagnosis in the European general population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

21 January 2018

Genetics of headaches

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

MRS shows abnormalities before symptoms in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

In vivo mapping of amyloid toxicity in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Grey and white matter changes at different stages of Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

Bench to beside: motivation for university industry partnership

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3134334

CNS response to a thermal stressor in human volunteers and rats may predict the clinical utility of analgesics

29 October 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

Voxel-Based Morphometry of the Human Brain: Methods and Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.584529

fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers

21 January 2018

1 reference

12 December 2020

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

1 reference

12 December 2020

Biomarkers: a valuable tool in clinical research and medical practice

1 reference

12 December 2020

Neurometabolic coupling in cerebral cortex reflects synaptic more than spiking activity

1 reference

12 December 2020

Reorganization of sensory processing below the level of spinal cord injury as revealed by fMRI

1 reference

12 December 2020

[Biomarkers: "Found in translation"]

1 reference

12 December 2020

The economics of drug development: a grim reality and a role for clinical pharmacology

1 reference

12 December 2020

Functional and pharmacological MRI in understanding brain function at a systems level

1 reference

12 December 2020

10.1517/17460441.2011.584529

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference