(Q34028615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Martino Monteverde

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Catharine M. West

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Karin Oien

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Margaret Frame

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Adrian Harris

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Gareth J Inman

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

9

Lindsay C Spender

1 reference

6 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

Adèle Hannigan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Paul Smith

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Gabriela Kalna

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Clare Orange

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Darren I O'Brien

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Reshma Shah

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Nelofer Syed

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Blanca Herrera

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Johanna K Thurlow

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Laura Lattanzio

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Meghan E Maurer

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jelena Mann

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

David C K Chu

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Max Patridge

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jonathan A Cooper

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Louise Hiller

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Linda J Nicholson

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Milena Gasco

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Tim Crook

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Francesca M Buffa

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

1 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

2842-2857

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

6 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2912175/fullTextXML

inferred from PubMed Central ID database lookup

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5 July 2018

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5 July 2018

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Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia

5 July 2018

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Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response

5 July 2018

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Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

5 July 2018

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The complex language of chromatin regulation during transcription

5 July 2018

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

5 July 2018

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Chromatin modifications and their function

5 July 2018

1 reference

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Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancer.

5 July 2018

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TGF beta inhibition for cancer therapy

5 July 2018

1 reference

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Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis

5 July 2018

1 reference

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The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH

5 July 2018

1 reference

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Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

5 July 2018

1 reference

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Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background

5 July 2018

1 reference

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Inhibition of TGFbeta signaling in cancer therapy

5 July 2018

1 reference

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Smad transcription factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Cytoplasmic PML function in TGF-beta signalling

5 July 2018

1 reference

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

5 July 2018

1 reference

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The two faces of transforming growth factor beta in carcinogenesis

5 July 2018

1 reference

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A multigenic program mediating breast cancer metastasis to bone

5 July 2018

1 reference

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

5 July 2018

1 reference

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Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

5 July 2018

1 reference

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Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer

5 July 2018

1 reference

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Identification of genes induced by BRCA1 in breast cancer cells

5 July 2018

1 reference

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Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

5 July 2018

1 reference

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Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

5 July 2018

1 reference

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Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

5 July 2018

1 reference

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TGF-beta signaling: positive and negative effects on tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

5 July 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Disabled-2 inactivation is an early step in ovarian tumorigenicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Transforming growth factor production by chemically transformed cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Associations between gene expressions in breast cancer and patient survival

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912175

Multiple microsample analysis of intratumor estrogen receptor distribution in breast cancers by a combined biochemical/immunohistochemical method

29 October 2018

1 reference

12 December 2020

Divergent routes to oral cancer

1 reference

12 December 2020

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder

1 reference

12 December 2020

Keeping order in the neighborhood: new roles for TGFbeta in maintaining epithelial homeostasis

1 reference

12 December 2020

1 reference

12 December 2020

Adaptor proteins and ubiquinators in TGF-beta signaling

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI36125

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20592473%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

20592473

1 reference