(Q34042190)

30 July 2017

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title

Keeping the immune system in check: a role for mitophagy (English)

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30 July 2017

Michael Lazarou

1

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language of work or name

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30 September 2014

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Immunology & Cell Biology

30 July 2017

published in

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30 July 2017

volume

93

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30 July 2017

issue

1

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30 July 2017

page(s)

3-10

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https://scigraph.springernature.com/pub.10.1038/icb.2014.75

30 July 2017

exact match

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cites work

Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial quality control: a matter of life and death for neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2014.75

The role of Atg proteins in autophagosome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Selective autophagy mediated by autophagic adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Atg8-family interacting motif crucial for selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Image-based genome-wide siRNA screen identifies selective autophagy factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Nix is a selective autophagy receptor for mitochondrial clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Essential role for Nix in autophagic maturation of erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 is degraded through the N-end rule pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Autoregulation of Parkin activity through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Regulation of Parkin E3 ubiquitin ligase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Structure of parkin reveals mechanisms for ubiquitin ligase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Ubiquitin is phosphorylated by PINK1 to activate parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Recognition of microorganisms and activation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The role of 'eat-me' signals and autophagy cargo receptors in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Susceptibility to leprosy is associated with PARK2 and PACRG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Human NLRP3 inflammasome activation is Nox1-4 independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Autophagy is essential for mitochondrial clearance in mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Redox control of NLRP3 inflammasome activation in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.75

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25267485

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The LIR motif - crucial for selective autophagy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25267485

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ICB.2014.75

1 reference

Dimensions Publication ID

30 July 2017

1020607253

0 references

1 reference