(Q34067184)

30 July 2017

title

Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format (English)

1 reference

30 July 2017

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1 reference

Timothy A Moeller

1

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30 July 2017

Sunita J Shukla

series ordinal

2

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30 July 2017

Menghang Xia

series ordinal

3

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30 July 2017

publication date

4 November 2011

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Assay and Drug Development Technologies

30 July 2017

published in

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30 July 2017

volume

10

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30 July 2017

issue

1

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30 July 2017

page(s)

78-87

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

30 July 2017

cites work

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Potassium dichromate induced cytotoxicity, genotoxicity and oxidative stress in human liver carcinoma (HepG2) cells

28 July 2018

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28 July 2018

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Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Hepatotoxicity in drug development: detection, significance and solutions

28 July 2018

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28 July 2018

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28 July 2018

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The metabolism and mode of action of gentian violet

28 July 2018

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An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes

28 July 2018

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A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

28 October 2018

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Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.

28 October 2018

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Toxicity testing in the 21st century: implications for human health risk assessment

28 October 2018

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Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis

28 October 2018

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Cellular imaging predictions of clinical drug-induced liver injury

28 October 2018

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Compound cytotoxicity profiling using quantitative high-throughput screening

28 October 2018

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28 October 2018

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In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system

28 October 2018

1 reference

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Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes

28 October 2018

1 reference

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Effects of malachite green (MG) and its major metabolite, leucomalachite green (LMG), in two human cell lines

28 October 2018

1 reference

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New technologies and screening strategies for hepatotoxicity: use of in vitro models

28 October 2018

1 reference

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Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge

28 October 2018

1 reference

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Toxicological effects of malachite green

28 October 2018

1 reference

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Acute Liver Failure in the United States

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

Mechanism of staurosporine-induced apoptosis in murine hepatocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

In vitro human tissue models in risk assessment: report of a consensus-building workshop

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

Mitochondrial effects of triarylmethane dyes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277728

The role of early in vivo toxicity testing in drug discovery toxicology

28 October 2018

1 reference

12 December 2020

Successful treatment of a patient suffering from severe acute potassium dichromate poisoning with liver transplantation

1 reference

12 December 2020

Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery

1 reference

12 December 2020

Clinico-pathologic correlation of liver damage in patients treated with 6-mercaptopurine and Adriamycin

1 reference

12 December 2020

Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance

1 reference

12 December 2020

Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone

1 reference

12 December 2020

Evaluation of drug metabolism, drug-drug interactions, and in vitro hepatotoxicity with cryopreserved human hepatocytes

1 reference

12 December 2020

Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria

1 reference

12 December 2020

Severe hepatotoxicity associated with troglitazone

1 reference

12 December 2020

Investigations into the liver effects of ximelagatran using high content screening of primary human hepatocyte cultures

1 reference

12 December 2020

Liver transplantation for potassium dichromate poisoning

1 reference

12 December 2020

Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential

1 reference

12 December 2020

Identifiers

DOI

10.1089/ADT.2010.0365

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30 July 2017

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30 July 2017

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