(Q34091442)

31 July 2017

5 references

29 May 2020

1 September 2020

14 November 2020

30 January 2021

13 January 2024

The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer (English)

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31 July 2017

8 references

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proto-oncogene protein

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1

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4 June 2020

Noriaki Sakuragi

series ordinal

6

1 reference

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4 June 2020

3

Hidemichi Watari

1 reference

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4 June 2020

2

Yosuke Konno

1 reference

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4 June 2020

4

Masayoshi Hosaka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Masayuki Noguchi

series ordinal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

1 reference

21 August 2014

13 references

Journal of Translational Medicine

31 July 2017

13 March 2019

14 March 2019

24 March 2019

3 April 2019

2 August 2019

28 September 2019

12 October 2019

18 December 2019

1 September 2020

14 November 2020

30 January 2021

13 January 2024

14 references

13 March 2019

14 March 2019

24 March 2019

3 April 2019

2 August 2019

28 September 2019

12 October 2019

18 December 2019

29 May 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 September 2020

14 November 2020

30 January 2021

13 January 2024

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

4 June 2020

copyright license

12 references

13 March 2019

14 March 2019

24 March 2019

3 April 2019

2 August 2019

28 September 2019

12 October 2019

18 December 2019

1 September 2020

14 November 2020

30 January 2021

13 January 2024

0 references

on focus list of Wikimedia project

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s12967-014-0231-0

0 references

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28 July 2018

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28 July 2018

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28 July 2018

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MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

28 July 2018

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MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer

28 July 2018

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28 July 2018

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Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways

28 July 2018

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Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

28 July 2018

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28 July 2018

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miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1.

28 July 2018

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Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma

28 July 2018

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Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.

28 July 2018

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Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM

28 July 2018

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MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN.

28 July 2018

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MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

28 July 2018

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

28 July 2018

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MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1

28 July 2018

1 reference

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MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer

28 July 2018

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28 July 2018

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PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer

28 July 2018

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Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endometrioid adenocarcinoma

28 July 2018

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MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells

28 July 2018

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

28 July 2018

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Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma

28 July 2018

1 reference

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A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas

28 July 2018

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28 July 2018

AKT-ing via microRNA.

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Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma

28 July 2018

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Invasive glioblastoma cells acquire stemness and increased Akt activation.

28 July 2018

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MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta

28 July 2018

1 reference

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Comprehensive miRNA profiling of surgically staged endometrial cancer

28 July 2018

1 reference

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The PI3K pathway as drug target in human cancer

28 July 2018

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A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer

28 July 2018

1 reference

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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

28 July 2018

1 reference

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Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium

28 July 2018

1 reference

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Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.

28 July 2018

1 reference

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PTEN inhibits BMI1 function independently of its phosphatase activity

28 July 2018

1 reference

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Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas.

28 July 2018

1 reference

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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

28 July 2018

1 reference

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

28 July 2018

1 reference

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Activation of epidermal growth factor receptor results in snail protein but not mRNA overexpression in endometrial cancer

28 July 2018

1 reference

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Current status of gynecologic cancer in Japan

28 July 2018

1 reference

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S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling

28 July 2018

1 reference

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Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal

28 July 2018

1 reference

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A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk

28 July 2018

1 reference

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The PTEN-PI3K pathway: of feedbacks and cross-talks

28 July 2018

1 reference

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Class I PI3K in oncogenic cellular transformation.

28 July 2018

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The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

28 July 2018

1 reference

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PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

28 July 2018

1 reference

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Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

The Snail genes as inducers of cell movement and survival: implications in development and cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Snail blocks the cell cycle and confers resistance to cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Cancer incidence trends in urban shanghai, 1972-1994: an update

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Two pathogenetic types of endometrial carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Serous carcinoma of the uterus-determination of HER-2/neu status using immunohistochemistry, chromogenic in situ hybridization, and quantitative polymerase chain reaction techniques: its significance and clinical correlation

28 July 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Endometrial carcinoma: molecular alterations involved in tumor development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

EZH2 is required for breast and pancreatic cancer stem cell maintenance and can be used as a functional cancer stem cell reporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

2 references

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.

28 October 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Prognostic significance of miR-205 in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNA-1 targets Slug and endows lung cancer A549 cells with epithelial and anti-tumorigenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Epithelial-mesenchymal plasticity in carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12967-014-0231-0

microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145234

The dualistic model of endometrial cancer: the challenge of classifying grade 3 endometrioid carcinoma

28 October 2018

1 reference

12 December 2020

Molecular profile of grade 3 endometrioid endometrial carcinoma: is it a type I or type II endometrial carcinoma?

1 reference

12 December 2020

Regulation, role, and targeting of Akt in cancer

1 reference

12 December 2020

Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

1 reference

12 December 2020

Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma

1 reference

12 December 2020

10.1186/S12967-014-0231-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25141911

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25141911%20AND%20SRC:MED&resulttype=core&format=json