(Q34103204)

31 July 2017

title

Improved siRNA/shRNA functionality by mismatched duplex (English)

1 reference

31 July 2017

Haoquan Wu

1

0 references

Hongming Ma

object named as

Hongming Ma

2

0 references

author name string

Chunting Ye

3

1 reference

31 July 2017

Danielle Ramirez

4

1 reference

31 July 2017

Shuiping Chen

5

1 reference

31 July 2017

Jessica Montoya

6

1 reference

31 July 2017

Premlata Shankar

7

1 reference

31 July 2017

Xiaozhong A Wang

8

1 reference

31 July 2017

N Manjunath

9

1 reference

31 July 2017

language of work or name

English

0 references

publication date

9 December 2011

1 reference

31 July 2017

1 reference

31 July 2017

volume

6

1 reference

31 July 2017

issue

12

1 reference

31 July 2017

page(s)

e28580

1 reference

Creative Commons Attribution 4.0 International

31 July 2017

copyright license

start time

9 December 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

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Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis

5 July 2018

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2'-O-methyl-modified anti-MDR1 fork-siRNA duplexes exhibiting high nuclease resistance and prolonged silencing activity

5 July 2018

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Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

5 July 2018

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Modulation of thermal stability can enhance the potency of siRNA

5 July 2018

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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

5 July 2018

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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

5 July 2018

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Optimization of duplex stability and terminal asymmetry for shRNA design

5 July 2018

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ATP-dependent human RISC assembly pathways

5 July 2018

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Alternative processing of primary microRNA transcripts by Drosha generates 5' end variation of mature microRNA.

5 July 2018

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RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs

5 July 2018

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Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells

5 July 2018

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

5 July 2018

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5 July 2018

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5 July 2018

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Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

5 July 2018

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

5 July 2018

1 reference

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The Argonaute protein family

5 July 2018

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Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

5 July 2018

1 reference

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Optimal design and validation of antiviral siRNA for targeting HIV-1.

5 July 2018

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5 July 2018

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Defining the optimal parameters for hairpin-based knockdown constructs

5 July 2018

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Sorting of Drosophila small silencing RNAs

5 July 2018

1 reference

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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Comparison of approaches for rational siRNA design leading to a new efficient and transparent method

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

An accurate and interpretable model for siRNA efficacy prediction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

On the art of identifying effective and specific siRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex

5 July 2018

1 reference

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Computational models with thermodynamic and composition features improve siRNA design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Structural basis for double-stranded RNA processing by Dicer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Design of a genome-wide siRNA library using an artificial neural network

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Processing of primary microRNAs by the Microprocessor complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

The Microprocessor complex mediates the genesis of microRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

DEQOR: a web-based tool for the design and quality control of siRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Improving the efficiency of RNA interference in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

In vivo activity of nuclease-resistant siRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Rational siRNA design for RNA interference

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Functional siRNAs and miRNAs Exhibit Strand Bias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Asymmetry in the assembly of the RNAi enzyme complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

The nuclear RNase III Drosha initiates microRNA processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

siRNA function in RNAi: a chemical modification analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Tolerance for mutations and chemical modifications in a siRNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

MicroRNA maturation: stepwise processing and subcellular localization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Analysis of gene function in somatic mammalian cells using small interfering RNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235145

Sequence characteristics of functional siRNAs

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028580

Predicting the efficacy of short oligonucleotides in antisense and RNAi experiments with boosted genetic programming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028580

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028580

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028580

Focusing on RISC assembly in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028580

Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3'- or 5'-end of the sense-stranded siRNA element

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22174840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A protocol for designing siRNAs with high functionality and specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22174840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22174840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0028580

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference