(Q34120058)

31 July 2017

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title

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. (English)

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31 July 2017

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Seamus J Martin

3

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author name string

Inna S Afonina

series ordinal

1

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31 July 2017

Sean P Cullen

series ordinal

2

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31 July 2017

publication date

1 May 2010

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31 July 2017

published in

Immunological Reviews

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31 July 2017

volume

235

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31 July 2017

issue

1

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31 July 2017

page(s)

105-116

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Many cuts to ruin: a comprehensive update of caspase substrates

31 July 2017

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Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

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Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency

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Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

21 January 2018

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Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.

21 January 2018

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Human and mouse granzyme A induce a proinflammatory cytokine response.

21 January 2018

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Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

21 January 2018

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Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.

21 January 2018

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B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.

21 January 2018

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Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis

21 January 2018

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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

21 January 2018

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Perforin-mediated target-cell death and immune homeostasis

21 January 2018

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Perforin and the granule exocytosis cytotoxicity pathway

21 January 2018

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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

21 January 2018

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

21 January 2018

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Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue

21 January 2018

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

21 January 2018

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Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

21 January 2018

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21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

21 January 2018

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

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Processing and activation of CMH-1 by granzyme B.

21 January 2018

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

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The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

21 January 2018

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Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

21 January 2018

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

21 January 2018

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Human and murine granzyme B exhibit divergent substrate preferences

21 January 2018

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

21 January 2018

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21 January 2018

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

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Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

21 January 2018

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Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death

21 January 2018

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Apoptosis: calling time on apoptosome activity

21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Executioner caspase-3 and caspase-7 are functionally distinct proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Non-apoptotic functions of granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Herpes Simplex Virus-Specific Memory CD8+ T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.

21 January 2018

1 reference

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Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Nucleolin is required for efficient nuclear egress of herpes simplex virus type 1 nucleocapsids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Activated CD4+CD25+ T cells selectively kill B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Expression of endogenous granzyme B in a subset of human primary breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

21 January 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

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The caspase-1 inflammasome: a pilot of innate immune responses

21 January 2018

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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The danger model: a renewed sense of self

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

The extra domain A of fibronectin activates Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Altered levels and molecular forms of granzyme k in plasma from septic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Antihemostatic Activity of Human Granzyme B Mediated by Cleavage of von Willebrand Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00908.X

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

21 January 2018

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10.1111/J.0105-2896.2010.00908.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference