(Q34157359)

31 July 2017

title

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria (English)

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31 July 2017

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25

Dyann Wirth

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31 July 2017

David A Fidock

12

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Amanda K Lukens

18

object named as

Amanda K Lukens

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31 July 2017

Craig J Thomas

22

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ORCID Public Data File 2021

Stuart Schreiber

31

object named as

Stuart Schreiber

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31 July 2017

author name string

Richard W Heidebrecht

1

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31 July 2017

Carol Mulrooney

2

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31 July 2017

Christopher P Austin

3

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31 July 2017

Robert H Barker

4

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31 July 2017

Jennifer A Beaudoin

5

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31 July 2017

Ken Chih-Chien Cheng

6

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31 July 2017

Eamon Comer

7

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31 July 2017

Sivaraman Dandapani

8

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31 July 2017

Justin Dick

9

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31 July 2017

Jeremy R Duvall

10

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31 July 2017

Eric H Ekland

11

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31 July 2017

Mark E Fitzgerald

13

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31 July 2017

Michael Foley

14

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31 July 2017

Rajarshi Guha

15

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31 July 2017

Paul Hinkson

16

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31 July 2017

Martin Kramer

17

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31 July 2017

Daniela Masi

19

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31 July 2017

Lisa A Marcaurelle

20

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31 July 2017

Xin-Zhuan Su

21

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31 July 2017

Michel Weïwer

23

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31 July 2017

Roger C Wiegand

24

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31 July 2017

Menghang Xia

26

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31 July 2017

Jing Yuan

27

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31 July 2017

Jinghua Zhao

28

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31 July 2017

Michelle Palmer

29

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31 July 2017

Benito Munoz

30

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31 July 2017

publication date

22 December 2011

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ACS Medicinal Chemistry Letters

31 July 2017

published in

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31 July 2017

volume

3

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31 July 2017

issue

2

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31 July 2017

page(s)

112-117

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Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Target identification and validation of novel antimalarials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Road towards new antimalarials - overview of the strategies and their chemical progress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Equity and adequacy of international donor assistance for global malaria control: an analysis of populations at risk and external funding commitments

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

The selection landscape of malaria parasites.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

New medicines to improve control and contribute to the eradication of malaria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Application of natural product-inspired diversity-oriented synthesis to drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Malaria: progress, perils, and prospects for eradication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Towards the optimal screening collection: a synthesis strategy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

High-throughput Plasmodium falciparum growth assay for malaria drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

A planning strategy for diversity-oriented synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Target-oriented and diversity-oriented organic synthesis in drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276110

28 October 2018

Identifiers

DOI

10.1021/ML200244K

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31 July 2017

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31 July 2017

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