(Q34268889)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22511596%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory (English)

1 reference

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29 January 2020

8

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29 January 2020

Tomris Mustafa

4

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29 January 2020

María Lourdes Arbonés

10

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29 January 2020

6

Helena C Parkington

1 reference

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29 January 2020

author name string

Katherine R Martin

1

1 reference

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29 January 2020

Alicia Corlett

2

1 reference

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29 January 2020

Daphne Dubach

3

1 reference

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29 January 2020

Harold A Coleman

5

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29 January 2020

Tobias D Merson

7

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29 January 2020

Sílvia Porta

9

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29 January 2020

David I Finkelstein

11

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29 January 2020

Melanie A Pritchard

12

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29 January 2020

publication date

17 April 2012

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29 January 2020

published in

Human Molecular Genetics

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29 January 2020

volume

21

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29 January 2020

issue

13

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29 January 2020

page(s)

3025-3041

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Verbal short-term memory in Down's syndrome: an articulatory loop deficit?

29 January 2020

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The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

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Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.

21 January 2018

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Loss of neurones from cortical and subcortical areas in Down's syndrome patients at middle age. Quantitative comparisons with younger Down's patients and patients with Alzheimer's disease

21 January 2018

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Functional neurogenesis in the adult hippocampus

21 January 2018

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Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.

21 January 2018

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A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

21 January 2018

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Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus.

21 January 2018

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A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

21 January 2018

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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

21 January 2018

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

21 January 2018

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Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

21 January 2018

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Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis.

21 January 2018

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Brain expression of the calcineurin inhibitor RCAN1 (Adapt78).

21 January 2018

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Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress.

21 January 2018

1 reference

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RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

21 January 2018

1 reference

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Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway

21 January 2018

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

21 January 2018

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Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function

21 January 2018

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Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effects

21 January 2018

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Molecular genetic analysis of the calcineurin signaling pathways

21 January 2018

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Calcineurin in memory and bidirectional plasticity

21 January 2018

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The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS134

The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS134

Long-Term Potentiation and Memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS134

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS134

Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene

21 January 2018

1 reference

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Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway

21 January 2018

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Noggin expands neural stem cells in the adult hippocampus

21 January 2018

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The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.

21 January 2018

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The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

21 January 2018

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The molecular basis of CaMKII function in synaptic and behavioural memory

21 January 2018

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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

21 January 2018

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Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia.

21 January 2018

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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons

21 January 2018

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Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons

21 January 2018

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Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

21 January 2018

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Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.

21 January 2018

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Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

21 January 2018

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Dendritic anomalies in disorders associated with mental retardation

21 January 2018

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Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

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Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

21 January 2018

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Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

21 January 2018

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

21 January 2018

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Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice.

21 January 2018

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Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

21 January 2018

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Learning and memory as a function of age in Down syndrome: a study using animal-based tasks

21 January 2018

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A synaptic model of memory: long-term potentiation in the hippocampus

21 January 2018

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Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus

21 January 2018

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Glutamate receptors and signal transduction in learning and memory

21 January 2018

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Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.

21 January 2018

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Regulator of calcineurin 1 mediates pathological vascular wall remodeling

21 January 2018

1 reference

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Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

21 January 2018

1 reference

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Mice: Individual Recognition by Olfactory Cues

21 January 2018

1 reference

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A two-trial memory task with automated recording: study in young and aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS134

The neurobiological basis of spontaneous alternation

21 January 2018

1 reference

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Developments of a water-maze procedure for studying spatial learning in the rat

21 January 2018

1 reference

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The transcriptional coactivator Querkopf controls adult neurogenesis.

21 January 2018

1 reference

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Unbiased stereological estimation of the number of neurons in the human hippocampus.

21 January 2018

1 reference

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

21 January 2018

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Null mutation of the alpha4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices

21 January 2018

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Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDS134

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22511596%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference