(Q34302413)

1 August 2017

title

Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations. (English)

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1 August 2017

Guanghong Wei

5

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author name string

Yun Zhang

1

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1 August 2017

Yin Luo

2

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1 August 2017

Yonghua Deng

3

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1 August 2017

Yuguang Mu

4

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1 August 2017

language of work or name

English

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publication date

31 May 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

5

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1 August 2017

page(s)

e38191

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

31 May 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

molecular dynamics simulation

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Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective

inferred from title

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364971

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

6 July 2018

1 reference

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Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

6 July 2018

1 reference

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Interactions of Aβ25-35 β-barrel-like oligomers with anionic lipid bilayer and resulting membrane leakage: an all-atom molecular dynamics study

6 July 2018

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The molecular basis of distinct aggregation pathways of islet amyloid polypeptide

6 July 2018

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Stable and metastable states of human amylin in solution.

6 July 2018

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Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

6 July 2018

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Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

6 July 2018

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Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

6 July 2018

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Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide

6 July 2018

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Insertion of short transmembrane helices by the Sec61 translocon

6 July 2018

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Sequence and crowding effects in the aggregation of a 10-residue fragment derived from islet amyloid polypeptide

6 July 2018

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Amyloidogenesis abolished by proline substitutions but enhanced by lipid binding

6 July 2018

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Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide

6 July 2018

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Dynamic -Helix Structure of Micelle-bound Human Amylin

6 July 2018

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Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

6 July 2018

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Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding

6 July 2018

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Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

6 July 2018

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Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

6 July 2018

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Mechanism of islet amyloid polypeptide fibrillation at lipid interfaces studied by infrared reflection absorption spectroscopy

6 July 2018

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Acyl chain order parameter profiles in phospholipid bilayers: computation from molecular dynamics simulations and comparison with 2H NMR experiments

6 July 2018

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Setting up and running molecular dynamics simulations of membrane proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364971

Membrane interaction of islet amyloid polypeptide

6 July 2018

1 reference

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Amyloid ion channels: a common structural link for protein-misfolding disease

6 July 2018

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Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

6 July 2018

1 reference

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Molecular dynamics simulations of lipid bilayers: major artifacts due to truncating electrostatic interactions.

6 July 2018

1 reference

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The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

6 July 2018

1 reference

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Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

6 July 2018

1 reference

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VMD: visual molecular dynamics

6 July 2018

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

6 July 2018

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

6 July 2018

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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

6 July 2018

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Phospholipid catalysis of diabetic amyloid assembly

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Lipid membranes modulate the structure of islet amyloid polypeptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Effect of the disulfide bond on the monomeric structure of human amylin studied by combined Hamiltonian and temperature replica exchange molecular dynamics simulations

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Structural diversity of the soluble trimers of the human amylin(20-29) peptide revealed by molecular dynamics simulations

21 January 2018

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The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Conserved and Cooperative Assembly of Membrane-Bound α-Helical States of Islet Amyloid Polypeptide†

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Cholesterol promotes the interaction of Alzheimer β-amyloid monomer with lipid bilayer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364971

Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amyloid polypeptide in explicit water

28 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Are fibrilgrowth and membrane damage linked processes? An experimental and computational study of IAPP12–18and IAPP21–27peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038191

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

21 January 2018

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12 December 2020

Molecular dynamics simulation of a phosphatidylglycerol membrane

1 reference

12 December 2020

Islet amyloid polypeptide inserts into phospholipid monolayers as monomer

1 reference

12 December 2020

Binding free energy and counterion release for adsorption of the antimicrobial peptide lactoferricin B on a POPG membrane

1 reference

12 December 2020

Comparing the structural properties of human and rat islet amyloid polypeptide by MD computer simulations

1 reference

12 December 2020

Phase behavior of mixtures of DPPC and POPG

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0038191

Identifiers

DOI

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1 August 2017

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1 August 2017

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