(Q34352365)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Thrombin inhibition by serpins disrupts exosite II (English)

1 reference

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14 February 2020

1

1 reference

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14 February 2020

Nicola Pozzi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

Daniel J D Johnson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Ty E Adams

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Vincenzo De Filippis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

James A Huntington

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

language of work or name

English

0 references

publication date

2 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

14 February 2020

published in

1 reference

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14 February 2020

volume

285

1 reference

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14 February 2020

issue

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

38621-38629

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

Serpins in thrombosis, hemostasis and fibrinolysis

14 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Shape-shifting serpins--advantages of a mobile mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Crystal structure of wild-type human thrombin in the Na+-free state.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Molecular recognition mechanisms of thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Serpin structure, mechanism, and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Structure of a serpin-protease complex shows inhibition by deformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Molecular mapping of the heparin-binding exosite of thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992294

Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)β → ser)

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

Conformational changes in thrombin when complexed by serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

Fibrinogen gamma' chain binds thrombin exosite II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

Crystal structure of thrombin bound to heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.144964

Activation-induced exposure of the thrombin anion-binding exosite. Interactions of recombinant mutant prothrombins with thrombomodulin and a thrombin exosite-specific antibody

21 January 2018

1 reference

12 December 2020

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

1 reference

12 December 2020

Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity

1 reference

12 December 2020

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

1 reference

12 December 2020

Crystal structure of thrombin in complex with fibrinogen gamma' peptide

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.144964

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20889971%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference