(Q34365755)

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Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

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PubMed publication ID

1 August 2017

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair (English)

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Europe PubMed Central

PubMed publication ID

1 August 2017

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Peng Lv

1

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Europe PubMed Central

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1 August 2017

Yue Wang

2

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Europe PubMed Central

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1 August 2017

Jie Ma

3

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Europe PubMed Central

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1 August 2017

Zheng Wang

4

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Europe PubMed Central

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1 August 2017

Jing-Li Li

5

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Europe PubMed Central

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1 August 2017

Christopher S Hong

6

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1 August 2017

Zhengping Zhuang

7

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1 August 2017

Yi-Xin Zeng

8

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1 August 2017

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1 September 2014

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Europe PubMed Central

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1 August 2017

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1 August 2017

5

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1 August 2017

17

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Europe PubMed Central

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1 August 2017

7512-7524

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Europe PubMed Central

PubMed publication ID

1 August 2017

Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair

1 reference

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Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery.

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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

1 reference

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Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor

1 reference

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Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management

1 reference

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Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

1 reference

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6 July 2018

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice

1 reference

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6 July 2018

Phosphatases: providing safe passage through mitotic exit

1 reference

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Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy

1 reference

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Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

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6 July 2018

Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

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A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma

1 reference

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6 July 2018

Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

An overview of Cdk1-controlled targets and processes

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6 July 2018

The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma

1 reference

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6 July 2018

A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

1 reference

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6 July 2018

The genetics of the p53 pathway, apoptosis and cancer therapy

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6 July 2018

Recent advances in p53 research: an interdisciplinary perspective.

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6 July 2018

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

1 reference

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6 July 2018

Protein phosphatase 2A regulatory subunits and cancer.

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6 July 2018

Living on a break: cellular senescence as a DNA-damage response

1 reference

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6 July 2018

Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China

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6 July 2018

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

1 reference

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6 July 2018

Multiple pathways regulated by the tumor suppressor PP2A in transformation

1 reference

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6 July 2018

Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

TCTP protects from apoptotic cell death by antagonizing bax function

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6 July 2018

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

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6 July 2018

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

CIP2A inhibits PP2A in human malignancies

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6 July 2018

PP2A: unveiling a reluctant tumor suppressor

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A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner

1 reference

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6 July 2018

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

1 reference

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6 July 2018

The complexity of p53 stabilization and activation

1 reference

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6 July 2018

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4202140

6 July 2018

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

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Global cancer statistics, 2002

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Translationally controlled tumor protein is a target of tumor reversion

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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Advances in protein kinase B signalling: AKTion on multiple fronts

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Cell death by mitotic catastrophe: a molecular definition

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Fostriecin: chemistry and biology

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Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

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Surfing the p53 network

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Akt-induced cellular senescence: implication for human disease

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Novel chimeric gene promoters responsive to hypoxia and ionizing radiation.

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27 October 2018

[Gefitinib enhances the radiosensitivity of nasopharyngeal carcinoma cell line CNE2 in vitro]

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https://pubmed.ncbi.nlm.nih.gov/25245035

12 December 2020

based on heuristic

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[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25245035

12 December 2020

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Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series

1 reference

https://pubmed.ncbi.nlm.nih.gov/25245035

12 December 2020

based on heuristic

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Identifiers

10.18632/ONCOTARGET.2258

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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