(Q34365833)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

main subject

whole genome duplication

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

T.A. Lewis

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Cécile K Lopez

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Bastien Gerby

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Francoise Pflumio

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Thomas Mercher

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Andrew M Stern

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

John D Crispino

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

45

David E Root

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

23

Lei Wei

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

46

Stuart L Schreiber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

43

Paul A Clemons

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

19

Nicola J Tolliday

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

37

Christina A Scherer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

44

Steven A Carr

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Qiang Wen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Benjamin Goldenson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Serena J Silver

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Monica Schenone

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Vlado Dancik

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Ling-Zhi Wang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

W Frank An

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Xiaoyu Li

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Mark-Anthony Bray

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Clarisse Thiollier

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Lauren Diebold

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Laure Gilles

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Martha S Vokes

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Christopher B Moore

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Meghan Bliss-Moreau

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Lynn Verplank

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Rama Mishra

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Sasidhar Vemula

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Jianjian Shi

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Reuben Kapur

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Paola Ballerini

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

D Gary Gilliland

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Liat Goldberg

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Yehudit Birger

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Shai Izraeli

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Alan S Gamis

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Franklin O Smith

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

William G Woods

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Jeffrey Taub

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

James E Bradner

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Boon-Cher Goh

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Robert J Gould

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Anne E Carpenter

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

1 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

150

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

575-589

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

Normal and malignant megakaryopoiesis

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Aurora kinase-A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone-H3 phosphorylation in mouse oocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Aurora kinase inhibitors as anti-cancer therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Empirical Bayes analysis of quantitative proteomics experiments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Regulation of megakaryocyte maturation and platelet formation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Survivin is not required for the endomitotic cell cycle of megakaryocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Identifying the proteins to which small-molecule probes and drugs bind in cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Aurora-A kinase is essential for bipolar spindle formation and early development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

A quantitative analysis of kinase inhibitor selectivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Target deconvolution strategies in drug discovery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Reactome: a knowledge base of biologic pathways and processes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

A small molecule-kinase interaction map for clinical kinase inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

The cellular geography of aurora kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

The protein kinase complement of the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Increased megakaryocytopoiesis in Lyn-deficient mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613864

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22863010

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analyzing protein lists with large networks: edge-count probabilities in random graphs with given expected degrees

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22863010

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2012.06.032

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22863010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22863010%20AND%20SRC:MED&resulttype=core&format=json