(Q34451594)

2 August 2017

title

Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation (English)

1 reference

2 August 2017

Charles Brenner

2

0 references

author name string

Bo-Kuan Wu

series ordinal

1

1 reference

2 August 2017

language of work or name

1 reference

26 November 2014

1 reference

2 August 2017

number of pages

14

1 reference

inferred from page(s)

published in

Cell Reports

1 reference

2 August 2017

volume

9

1 reference

2 August 2017

issue

5

1 reference

2 August 2017

page(s)

1827-1840

1 reference

RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation

2 August 2017

cites work

1 reference

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

6 July 2018

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Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

6 July 2018

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6 July 2018

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An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes

6 July 2018

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TET enzymes, TDG and the dynamics of DNA demethylation.

6 July 2018

1 reference

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Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

6 July 2018

1 reference

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TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation

6 July 2018

1 reference

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RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

6 July 2018

1 reference

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Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

6 July 2018

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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.

6 July 2018

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

6 July 2018

1 reference

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Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

6 July 2018

1 reference

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6 July 2018

1 reference

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TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases

6 July 2018

1 reference

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Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

6 July 2018

1 reference

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

6 July 2018

1 reference

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

6 July 2018

1 reference

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Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation

6 July 2018

1 reference

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RAS oncogenes: weaving a tumorigenic web

6 July 2018

1 reference

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

6 July 2018

1 reference

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

6 July 2018

1 reference

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Active DNA demethylation: many roads lead to Rome.

6 July 2018

1 reference

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Mutation in TET2 in myeloid cancers

6 July 2018

1 reference

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

6 July 2018

1 reference

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

6 July 2018

1 reference

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Ras regulation of DNA-methylation and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

An elaborate pathway required for Ras-mediated epigenetic silencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Hyperactive Ras in developmental disorders and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Epidermal growth factor receptor mutations in lung cancer

6 July 2018

1 reference

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Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Hypermethylation of the GATA genes in lung cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Gene-promoter hypermethylation as a biomarker in lung cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Targeting RAS signalling pathways in cancer therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Cancer. Addiction to oncogenes--the Achilles heal of cancer

6 July 2018

1 reference

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Worms gang up on bacteria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Untangling the ErbB signalling network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

The DNA methyltransferases of mammals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Essential role for oncogenic Ras in tumour maintenance

6 July 2018

1 reference

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Role of DNA 5-methylcytosine transferase in cell transformation by fos

6 July 2018

1 reference

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Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

6 July 2018

1 reference

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Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

6 July 2018

1 reference

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

6 July 2018

1 reference

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Suppression of intestinal neoplasia by DNA hypomethylation.

6 July 2018

1 reference

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Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine

6 July 2018

1 reference

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Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

DNA methylation affecting the transforming activity of the human Ha-ras oncogene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4268240

K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466250

12 December 2020

inferred from PubMed ID database lookup

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466250

12 December 2020

inferred from PubMed ID database lookup

The fundamental role of epigenetic events in cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466250

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CELREP.2014.10.063

1 reference

2 August 2017

1 reference

2 August 2017

1 reference