(Q34493326)

English

Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

based on heuristic

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pharmacodynamics

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based on heuristic

inferred from title

object named as

Sean W Harshman

2

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Michael A. Freitas

object named as

Michael A Freitas

10

0 references

9

object named as

Guido Marcucci

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

8

object named as

John C Byrd

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Michael R Grever

7

object named as

Michael Grever

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Europe PubMed Central

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2 August 2017

3

object named as

Shujun Liu

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

author name string

Liwen Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Chen Ren

4

1 reference

Europe PubMed Central

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2 August 2017

Hua Xu

5

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Europe PubMed Central

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2 August 2017

Larry Sallans

6

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Europe PubMed Central

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2 August 2017

publication date

1 December 2010

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Europe PubMed Central

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2 August 2017

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Europe PubMed Central

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2 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

23

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

4281-4292

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status.

1 reference

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A hierarchical MS2/MS3 database search algorithm for automated analysis of phosphopeptide tandem mass spectra

1 reference

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The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

1 reference

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Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry

1 reference

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A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

1 reference

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Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster

1 reference

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The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

1 reference

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Identification and characterization of disulfide bonds in proteins and peptides from tandem MS data by use of the MassMatrix MS/MS search engine

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Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells

1 reference

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Development of a titanium dioxide nanoparticle pipette-tip for the selective enrichment of phosphorylated peptides

1 reference

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Protein phosphorylation analysis by site-specific arginine-mimic labeling in gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

1 reference

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Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma

1 reference

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A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data

1 reference

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Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells

1 reference

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6 July 2018

Enhancement of the efficiency of phosphoproteomic identification by removing phosphates after phosphopeptide enrichment

1 reference

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6 July 2018

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

1 reference

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6 July 2018

Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila

1 reference

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6 July 2018

Selective detection and identification of phosphopeptides by dansyl MS/MS/MS fragmentation

1 reference

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6 July 2018

Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1.

1 reference

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6 July 2018

New and automated MSn approaches for top-down identification of modified proteins

1 reference

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6 July 2018

Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors

1 reference

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6 July 2018

Heat shock proteins and acute leukemias

1 reference

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6 July 2018

Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

1 reference

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6 July 2018

Mapping sites of protein phosphorylation by mass spectrometry utilizing a chemical-enzymatic approach: characterization of products from alpha-S1 casein phosphopeptides

1 reference

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6 July 2018

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

1 reference

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6 July 2018

Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on pediatric acute lymphoblastic leukemia (ALL) with respect to Bcr-Abl status and imatinib mesylate sensitivity.

1 reference

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6 July 2018

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

1 reference

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Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry

1 reference

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6 July 2018

Hsp90 activation and cell cycle regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021470

6 July 2018

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

1 reference

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6 July 2018

Improved peptide identification in proteomics by two consecutive stages of mass spectrometric fragmentation

1 reference

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6 July 2018

Large-scale characterization of HeLa cell nuclear phosphoproteins

1 reference

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6 July 2018

Altered states: selectively drugging the Hsp90 cancer chaperone

1 reference

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6 July 2018

Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry.

1 reference

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6 July 2018

TANDEM: matching proteins with tandem mass spectra

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6 July 2018

The Secret Life of Histones

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6 July 2018

Characterization of protein phosphorylation by mass spectrometry using immobilized metal ion affinity chromatography with on-resin beta-elimination and Michael addition

1 reference

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6 July 2018

Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021470

6 July 2018

Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021470

6 July 2018

Characterization of phosphoproteins from electrophoretic gels by nanoscale Fe(III) affinity chromatography with off-line mass spectrometry analysis

1 reference

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6 July 2018

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021470

6 July 2018

On-membrane digestion of beta-casein for determination of phosphorylation sites by matrix-assisted laser desorption/ionization quadrupole/time-of-flight mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021470

6 July 2018

Rapid dephosphorylation of H1 histones after apoptosis induction

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6 July 2018

Detection and sequencing of phosphopeptides affinity bound to immobilized metal ion beads by matrix-assisted laser desorption/ionization mass spectrometry

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6 July 2018

Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

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6 July 2018

Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

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6 July 2018

Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.

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6 July 2018

Brassica napus hsp90 can autophosphorylate and phosphorylate other protein substrates.

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6 July 2018

Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry

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6 July 2018

Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts

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6 July 2018

Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation

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6 July 2018

The 90 kDa heat shock protein (hsp90) induces the condensation of the chromatin structure.

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6 July 2018

An approach to locate phosphorylation sites in a phosphoprotein: mass mapping by combining specific enzymatic degradation with matrix-assisted laser desorption/ionization mass spectrometry

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6 July 2018

A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

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6 July 2018

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells

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6 July 2018

Chromatin condensation: does histone H1 dephosphorylation play a role?

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6 July 2018

Influence of histone H1 on chromatin structure

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6 July 2018

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin

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6 July 2018

Characterization of post-translational modifications of the linker histones H1 and H5 from chicken erythrocytes using mass spectrometry

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27 October 2018

Antitumor activity of bortezomib alone and in combination with TRAIL in human acute myeloid leukemia.

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27 October 2018

Automatic validation of phosphopeptide identifications by the MS2/MS3 target-decoy search strategy.

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27 October 2018

Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells

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27 October 2018

Induction of histone H1.2 cytosolic release in chronic lymphocytic leukemia cells after genotoxic and non-genotoxic treatment

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27 October 2018

Analysis of effect of casein phosphopeptides on zinc binding using mass spectrometry.

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27 October 2018

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

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27 October 2018

[The heat shock protein 90 inhibitor induces apoptosis and differentiation of Kasumi-1 and its mechanisms].

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27 October 2018

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27 October 2018

Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death

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27 October 2018

Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.

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27 October 2018

Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.

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27 October 2018

Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia

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27 October 2018

Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway

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27 October 2018

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

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27 October 2018

Understanding global changes in histone H1 phosphorylation using mass spectrometry

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27 October 2018

Purification and analyses of histone H1 variants and H1 posttranslational modifications.

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27 October 2018

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

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27 October 2018

Phosphospecific proteolysis for mapping sites of protein phosphorylation

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27 October 2018

Flavonoid effects on normal and leukemic cells

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27 October 2018

Selective analysis of phosphopeptides within a protein mixture by chemical modification, reversible biotinylation and mass spectrometry

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27 October 2018

Phosphoprotein isotope-coded affinity tag approach for isolating and quantitating phosphopeptides in proteome-wide analyses

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27 October 2018

Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis

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27 October 2018

Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

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9 December 2018

Fragmentation of phosphopeptides in an ion trap mass spectrometer

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone, H1.2: another housekeeping protein that kills

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12 December 2020

based on heuristic

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Evidence for the involvement of H1 histone phosphorylation in chromosome condensation

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12 December 2020

based on heuristic

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Chemical modification of phosvitin: preparation of dimethylaminovitin and methylmercaptovitin and their utility for elucidation of phosvitin primary structure

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse temperature-sensitive mutant defective in H1 histone phosphorylation is defective in deoxyribonucleic acid synthesis and chromosome condensation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21110323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of confidence and reproducibility in quantitative proteomics performed by a capillary isoelectric focusing-based proteomic platform coupled with a spectral counting approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/21110323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence analysis of phosphoserine-containing peptides. Modification for picomolar sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21110323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective zirconium dioxide-based enrichment of phosphorylated peptides for mass spectrometric analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21110323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/21110323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PMIC.201000080

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

Sitelinks

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