(Q34535598)

2 August 2017

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title

Telomerase is not an oncogene (English)

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2 August 2017

Calvin B Harley

1

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

volume

21

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2 August 2017

issue

4

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2 August 2017

page(s)

494-502

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Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture

2 August 2017

cites work

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7 January 2021

The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells

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7 January 2021

Switching and signaling at the telomere

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7 January 2021

Genetics of proteolysis in Escherichia coli*.

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7 January 2021

Mechanism of telomerase induction during T cell activation

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7 January 2021

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

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7 January 2021

The biology of replicative senescence

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7 January 2021

Secondary structure of vertebrate telomerase RNA

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7 January 2021

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

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7 January 2021

Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

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7 January 2021

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

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7 January 2021

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

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7 January 2021

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

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7 January 2021

The RNA component of human telomerase

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7 January 2021

Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).

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7 January 2021

Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

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7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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7 January 2021

Telomere length regulation

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7 January 2021

Mammalian telomeres end in a large duplex loop

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7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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7 January 2021

Telomerase activity is sufficient to allow transformed cells to escape from crisis

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7 January 2021

Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro

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7 January 2021

Telomere loss: mitotic clock or genetic time bomb?

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Telomerase, Cell Immortality, and Cancer

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7 January 2021

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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7 January 2021

Correlating telomerase activity levels with human neuroblastoma outcomes

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7 January 2021

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase

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7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1 reference

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7 January 2021

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

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7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

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7 January 2021

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

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7 January 2021

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

1 reference

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7 January 2021

Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

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7 January 2021

Telomerase catalytic subunit homologs from fission yeast and human

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7 January 2021

Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.

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7 January 2021

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

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7 January 2021

Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomerase expression in primary neuroblastomas

1 reference

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7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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7 January 2021

Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

1 reference

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7 January 2021

Transplantation of Normal and DMD Myoblasts Expressing the Telomerase Gene in SCID Mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomerase allows the immortalization of T antigen-positive DMD myoblasts: a new source of cells for gene transfer application

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Tankyrase promotes telomere elongation in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Control of human telomere length by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Detection of telomerase activity in malignant and nonmalignant skin conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Developmental regulation of telomerase activity in human fetal tissues during gestation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Deficiency of colonic telomerase in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomere lengthening and telomerase activation during human B cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Regulated expression of telomerase activity in human T lymphocyte development and activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Human endothelial cell life extension by telomerase expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205076

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

Identifiers

DOI

10.1038/SJ.ONC.1205076

1 reference

Dimensions Publication ID

2 August 2017

1017932090

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1 reference