(Q34575828)

3 August 2017

title

Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis (English)

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3 August 2017

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Sergei A Novgorodov

1

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3 August 2017

Daria A Chudakova

2

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3 August 2017

Brian W Wheeler

3

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3 August 2017

Jacek Bielawski

4

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3 August 2017

Mark S Kindy

5

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3 August 2017

Lina M Obeid

6

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3 August 2017

Tatyana I Gudz

7

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3 August 2017

language of work or name

English

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publication date

10 December 2010

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3 August 2017

number of pages

15

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Journal of Biological Chemistry

inferred from page(s)

published in

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3 August 2017

volume

286

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3 August 2017

issue

6

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3 August 2017

page(s)

4644-4658

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Mitochondrial calcium channels

3 August 2017

cites work

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Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages

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7 July 2018

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Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

7 July 2018

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Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention

7 July 2018

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Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

7 July 2018

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Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells

7 July 2018

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A cell-biological model of p75NTR signaling

7 July 2018

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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

7 July 2018

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Intracellular trafficking of sphingolipids: relationship to biosynthesis

7 July 2018

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Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

7 July 2018

1 reference

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Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction

7 July 2018

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LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity

7 July 2018

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Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

7 July 2018

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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Glutamate-mediated glial injury: mechanisms and clinical importance

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

The ins and outs of sphingolipid synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Different effects of long- and short-chain ceramides on the gel-fluid and lamellar-hexagonal transitions of phospholipids: a calorimetric, NMR, and x-ray diffraction study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

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7 July 2018

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Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

The neurotrophin receptor p75NTR as a positive modulator of myelination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Ceramide: second messenger or modulator of membrane structure and dynamics?

7 July 2018

1 reference

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De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

7 July 2018

1 reference

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The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

7 July 2018

1 reference

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Combinatorial ganglioside biosynthesis

7 July 2018

1 reference

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Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Cell death in early neural development: beyond the neurotrophic theory

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Compartmentalization of ceramide signaling: physical foundations and biological effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Molecular cloning and characterization of a human mitochondrial ceramidase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Axonal control of oligodendrocyte development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Calpain regulates actin remodeling during cell spreading

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Specificity in Ceramide Biosynthesis from Long Chain Bases and Various Fatty Acyl Coenzyme A's by Brain Microsomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Enzymatic formation of hydroxy ceramides and comparison with enzymes forming nonhydroxy ceramides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

A role for the mitochondrion in the protection of cells against calcium overload?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Cell death and control of cell survival in the oligodendrocyte lineage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

The mitochondrial calcium uniporter is a highly selective ion channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Excitotoxic injury to mitochondria isolated from cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

New light on white matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Submitochondrial localization of associated mu-calpain and calpastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039377

Ceramide-mediated clustering is required for CD95-DISC formation

27 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

21 January 2018

Apoptosis in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164392

Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria

21 January 2018

1 reference

12 December 2020

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1 reference

12 December 2020

Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses

1 reference

12 December 2020

Fatty acyl-Co A: sphingosine acyltransferase in bovine brain mitochondria: its solubilization and reconstitution onto the membrane lipid liposomes

1 reference

12 December 2020

Autolysis, Ca2+Requirement, and Heterodimer Stability in m-Calpain

1 reference

12 December 2020

Oligodendrocyte apoptosis mediated by caspase activation

1 reference

12 December 2020

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

1 reference

12 December 2020

Dual responses of CNS mitochondria to elevated calcium

1 reference

12 December 2020

Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.164392

1 reference

3 August 2017

1 reference

3 August 2017

1 reference