(Q34611548)

English

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

allosteric inhibitor

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based on heuristic

inferred from title

Mamuka Kvaratskhelia

15

object named as

Mamuka Kvaratskhelia

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Alison Slaughter

1

1 reference

Europe PubMed Central

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3 August 2017

Kellie A Jurado

2

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Europe PubMed Central

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3 August 2017

Nanjie Deng

3

1 reference

Europe PubMed Central

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3 August 2017

Lei Feng

4

1 reference

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3 August 2017

Jacques J Kessl

5

1 reference

Europe PubMed Central

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3 August 2017

Nikoloz Shkriabai

6

1 reference

Europe PubMed Central

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3 August 2017

Ross C Larue

7

1 reference

Europe PubMed Central

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3 August 2017

Hind J Fadel

8

1 reference

Europe PubMed Central

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3 August 2017

Pratiq A Patel

9

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Europe PubMed Central

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3 August 2017

Nivedita Jena

10

1 reference

Europe PubMed Central

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3 August 2017

James R Fuchs

11

1 reference

Europe PubMed Central

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3 August 2017

Eric Poeschla

12

1 reference

Europe PubMed Central

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3 August 2017

Ronald M Levy

13

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3 August 2017

Alan Engelman

14

1 reference

Europe PubMed Central

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3 August 2017

publication date

25 November 2014

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Europe PubMed Central

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3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

11

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Europe PubMed Central

PubMed publication ID

3 August 2017

100

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution 4.0 International

25 November 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

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Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

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TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

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Allosteric Inhibition of Human Immunodeficiency Virus Integrase

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The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

1 reference

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LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

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7 July 2018

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain

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7 July 2018

Allosteric inhibition of HIV-1 integrase activity

1 reference

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7 July 2018

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

1 reference

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7 July 2018

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

1 reference

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7 July 2018

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7 July 2018

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

1 reference

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7 July 2018

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251946

7 July 2018

HIV integrase as a target for antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251946

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Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

1 reference

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Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing

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New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4251946

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

1 reference

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Elucidating the energetics of entropically driven protein-ligand association: calculations of absolute binding free energy and entropy

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FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

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Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143.

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Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy

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1 reference

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

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12 December 2020

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10.1186/S12977-014-0100-1

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Europe PubMed Central

PubMed publication ID

3 August 2017

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

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Europe PubMed Central

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3 August 2017

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