(Q27680666)

25 June 2017

title

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage (English)

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25 June 2017

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Damien Bonnard

2

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Alessia Zamborlini

object named as

Alessia Zamborlini

17

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author name string

Erwann Le Rouzic

1

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25 June 2017

Sophie Chasset

3

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25 June 2017

Jean-Michel Bruneau

4

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25 June 2017

Francis Chevreuil

5

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25 June 2017

Frédéric Le Strat

6

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25 June 2017

Juliette Nguyen

7

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25 June 2017

Roxane Beauvoir

8

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25 June 2017

Céline Amadori

9

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25 June 2017

Julie Brias

10

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25 June 2017

Sophie Vomscheid

11

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25 June 2017

Sylvia Eiler

12

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25 June 2017

Nicolas Lévy

13

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25 June 2017

Olivier Delelis

14

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25 June 2017

Eric Deprez

15

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25 June 2017

Ali Saïb

16

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25 June 2017

Stéphane Emiliani

18

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25 June 2017

Marc Ruff

19

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25 June 2017

Benoit Ledoussal

20

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25 June 2017

François Moreau

21

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25 June 2017

Richard Benarous

22

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25 June 2017

publication date

21 November 2013

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25 June 2017

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25 June 2017

volume

10

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25 June 2017

issue

1

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page(s)

144

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describes a project that uses

25 June 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4222603/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

1 reference

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

20 March 2017

1 reference

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The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

20 March 2017

1 reference

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New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

20 March 2017

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

20 March 2017

1 reference

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Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

20 March 2017

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

20 March 2017

1 reference

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Retroviral intasome assembly and inhibition of DNA strand transfer

20 March 2017

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Structural basis for functional tetramerization of lentiviral integrase

20 March 2017

1 reference

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

20 March 2017

1 reference

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

20 March 2017

1 reference

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Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

20 March 2017

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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20 March 2017

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Molecular replacement with MOLREP

20 March 2017

1 reference

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A graphical user interface to the CCP4 program suite

20 March 2017

1 reference

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

An essential role for LEDGF/p75 in HIV integration

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

20 March 2017

1 reference

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

20 March 2017

1 reference

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Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor

7 April 2017

1 reference

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Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Evolution of HIV integrase resistance mutations.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Fragmentation-tree density representation for crystallographic modelling of bound ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Interfacial inhibitors: targeting macromolecular complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Raltegravir: the first HIV‐1 integrase strand transfer inhibitor in the HIV armamentarium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Resistance to HIV-1 integrase inhibitors: A structural perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

The role of lysine 186 in HIV-1 integrase multimerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

A role for LEDGF/p75 in targeting HIV DNA integration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Colinearity of Reverse Transcriptase Inhibitor Resistance Mutations Detected by Population-Based Sequencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

HeLa-LAV, an epithelial cell line stably infected with HIV-1

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222603

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1742-4690-10-144

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1742-4690-10-144

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1742-4690-10-144

21 January 2018

Identifiers

DOI

10.1186/1742-4690-10-144

1 reference

Dimensions Publication ID

25 June 2017

1040153847

0 references

OpenCitations bibliographic resource ID

1636983

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1636983

1 reference