(Q34659234)

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Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice (English)

1 reference

Europe PubMed Central

3 August 2017

author name string

W Härtig

1

1 reference

Europe PubMed Central

3 August 2017

A Saul

2

1 reference

Europe PubMed Central

3 August 2017

J Kacza

3

1 reference

Europe PubMed Central

3 August 2017

J Grosche

4

1 reference

Europe PubMed Central

3 August 2017

S Goldhammer

5

1 reference

Europe PubMed Central

3 August 2017

D Michalski

6

1 reference

Europe PubMed Central

3 August 2017

O Wirths

7

1 reference

Europe PubMed Central

3 August 2017

language of work or name

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based on heuristic

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publication date

1 February 2014

1 reference

Europe PubMed Central

3 August 2017

Neuropathology and Applied Neurobiology

1 reference

Europe PubMed Central

3 August 2017

40

1 reference

Europe PubMed Central

3 August 2017

2

1 reference

Europe PubMed Central

3 August 2017

106-120

1 reference

Europe PubMed Central

3 August 2017

Alzheimer disease models and human neuropathology: similarities and differences

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21 January 2018

Do amyloid oligomers act as traps for misfolded proteins? A hypothesis

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Corruption and spread of pathogenic proteins in neurodegenerative diseases

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21 January 2018

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

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Neurodegenerative tauopathies

1 reference

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Selective loss of central cholinergic neurons in Alzheimer's disease

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Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

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Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease

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21 January 2018

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

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21 January 2018

The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

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21 January 2018

Alzheimer's disease: Abeta, tau and synaptic dysfunction

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Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

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'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

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21 January 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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21 January 2018

Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

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21 January 2018

Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.

1 reference

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21 January 2018

Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice

1 reference

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21 January 2018

Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling

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21 January 2018

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12050

21 January 2018

Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning

1 reference

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21 January 2018

Interneurons of the hippocampus

1 reference

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21 January 2018

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.

1 reference

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21 January 2018

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12050

21 January 2018

Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

1 reference

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21 January 2018

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12050

21 January 2018

Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice.

1 reference

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21 January 2018

Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration

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21 January 2018

Cholinergic immunolesions by 192IgG-saporin--useful tool to simulate pathogenic aspects of Alzheimer's disease

1 reference

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21 January 2018

Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice

1 reference

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21 January 2018

Using the subcortically lesioned rat cortex to understand the physiological role of amyloid precursor protein.

1 reference

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Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

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21 January 2018

Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions?

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Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease

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The cholinergic system in aging and neuronal degeneration

1 reference

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21 January 2018

The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases

1 reference

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Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy.

1 reference

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21 January 2018

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications

1 reference

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Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes

1 reference

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21 January 2018

Cholinergic neuropathology in a mouse model of Alzheimer's disease

1 reference

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21 January 2018

Degeneration of beta-amyloid-associated cholinergic structures in transgenic APP SW mice.

1 reference

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Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway

1 reference

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21 January 2018

GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus.

1 reference

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Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.

1 reference

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Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein

1 reference

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories

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Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

1 reference

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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A specific amyloid-beta protein assembly in the brain impairs memory

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

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Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

1 reference

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Tau protein as a differential biomarker of tauopathies

1 reference

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1 reference

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Animal models of Alzheimer's disease and frontotemporal dementia

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Tauopathy models and human neuropathology: similarities and differences

1 reference

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Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions

1 reference

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

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Tau phosphorylation in Alzheimer's disease: pathogen or protector?

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Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

1 reference

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Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

1 reference

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

1 reference

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

1 reference

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EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

1 reference

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Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

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Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue

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Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behavior.

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Microglia and neuroprotection: implications for Alzheimer's disease

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5 June 2022

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Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice.

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Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy.

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Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

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General and dramatic glial reaction in Alzheimer brains

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Identifiers

10.1111/NAN.12050

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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