(Q34663219)

3 August 2017

Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase (English)

1 reference

3 August 2017

6

Heidi C E Welch

1 reference

3 August 2017

Mark A Barber

1

1 reference

3 August 2017

Sarah Donald

2

1 reference

3 August 2017

Sylvia Thelen

3

1 reference

3 August 2017

Karen E Anderson

4

1 reference

3 August 2017

Marcus Thelen

5

1 reference

3 August 2017

language of work or name

English

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publication date

13 August 2007

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Journal of Biological Chemistry

3 August 2017

1 reference

3 August 2017

282

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3 August 2017

29967-29976

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3 August 2017

41

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Rho GTPases in cell biology

3 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

P-Rex2, a new guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

P-Rex1 regulates neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Purification of P-Rex1 from neutrophils and nucleotide exchange assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Phosphoinositide 3-kinase-dependent activation of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Pak1 and PIX regulate contact inhibition during epithelial wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Regulation of proto-Dbl by intracellular membrane targeting and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701877200

21 January 2018

Identifiers

DOI

10.1074/JBC.M701877200

1 reference

3 August 2017

1 reference