(Q34686567)

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Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

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Europe PubMed Central

PubMed publication ID

3 August 2017

Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

based on heuristic

inferred from title

William J Placzek

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Jun Wei

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Shinichi Kitada

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

John L Stebbins

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Dayong Zhai

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Bainan Wu

6

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Michele F Rega

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Ziming Zhang

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Jason Cellitti

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Li Yang

10

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Russell Dahl

11

1 reference

Europe PubMed Central

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3 August 2017

John C Reed

12

1 reference

Europe PubMed Central

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3 August 2017

Maurizio Pellecchia

13

1 reference

Europe PubMed Central

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3 August 2017

language of work or name

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publication date

29 October 2010

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Europe PubMed Central

PubMed publication ID

3 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

3 August 2017

53

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Europe PubMed Central

PubMed publication ID

3 August 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

8000-8011

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms

1 reference

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7 July 2018

Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure-based discovery of a new class of Bcl-xL antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Killing cancer cells by flipping the Bcl-2/Bax switch.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Apoptosis-based therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Dysregulation of apoptosis in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Development and validation of a genetic algorithm for flexible docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Probing substrate binding site of the Escherichia coli quinol oxidases using synthetic ubiquinol analogues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Differential effects of Bcl-2 on T and B cells in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

7 July 2018

Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

26 October 2018

Direct and selective arylation of tertiary silanes with rhodium catalyst

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

26 October 2018

Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

26 October 2018

Molecular biology of chronic lymphocytic leukemia: implications for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059195

26 October 2018

Synthesis and cytotoxicity of gossypol related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Texture mapping: a new tool for molecular graphics

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell Death in Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

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inferred from PubMed ID database lookup

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21033669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM100746Q

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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