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Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.
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Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
title
Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
author
Peter C Butler
series ordinal
5
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Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
author name string
Marie Daval
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1
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Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Tatyana Gurlo
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2
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Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Safia Costes
series ordinal
3
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Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Chang-Jiang Huang
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
language of work or name
English
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publication date
4 March 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
number of pages
12
1 reference
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inferred from page(s)
published in
Diabetes
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
volume
60
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
page(s)
1186-1197
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
copyright license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
start time
27 August 2021
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stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Regulating insulin signaling and beta-cell function through IRS proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Integrin-regulated FAK-Src signaling in normal and cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Cdk5-dependent regulation of glucose-stimulated insulin secretion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
A decade of CDK5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Functional impact of attachment and purification in the short term culture of human pancreatic islets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
7 July 2018
Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Cyclin-dependent kinase 5 promotes insulin exocytosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
Long-term culture of human pancreatic islets in an extracellular matrix: morphological and metabolic effects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064092
retrieved
26 October 2018
p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21378178
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of Glucose and 3′,5′-Cyclic Adenosine Monophosphate upon Reaggregation of Single Pancreatic B-Cells*
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21378178
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Signaling by integrin receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21378178
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2337/DB10-1048
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PMC publication ID
3064092
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PubMed publication ID
21378178
1 reference
stated in
Europe PubMed Central
PMC publication ID
3064092
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21378178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
ResearchGate publication ID
50289371
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