(Q34723257)

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1) (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Annik Prat

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Nabil G Seidah

6

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author name string

Maryssa Canuel

1

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Europe PubMed Central

PubMed publication ID

4 August 2017

Xiaowei Sun

2

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Europe PubMed Central

PubMed publication ID

4 August 2017

Marie-Claude Asselin

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

Eustache Paramithiotis

4

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Europe PubMed Central

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4 August 2017

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publication date

13 May 2013

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

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Europe PubMed Central

PubMed publication ID

4 August 2017

5

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Europe PubMed Central

PubMed publication ID

4 August 2017

e64145

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Creative Commons Attribution 4.0 International

13 May 2013

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3652815/fullTextXML

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Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

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The biology and therapeutic targeting of the proprotein convertases

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PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

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LDL cholesterol: the lower the better

1 reference

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Low-density lipoprotein receptor-related protein 1: new functions for an old molecule

1 reference

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A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor

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Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events

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Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

1 reference

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Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels

1 reference

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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

1 reference

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LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies

1 reference

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Molecular basis for LDL receptor recognition by PCSK9

1 reference

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7 July 2018

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

1 reference

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

1 reference

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The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

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The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions

1 reference

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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

1 reference

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

1 reference

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

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Proprotein convertases: lessons from knockouts

1 reference

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

1 reference

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Role of cholesterol and lipid organization in disease

1 reference

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

1 reference

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

1 reference

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

1 reference

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

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1 reference

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1 reference

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1 reference

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Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

1 reference

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21 January 2018

PCSK9 as a therapeutic target of dyslipidemia

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0064145

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0064145

21 January 2018

Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain

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21 January 2018

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0064145

21 January 2018

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised con

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[Multiple involvements of LRP-1 receptor in tumor progression].

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21 January 2018

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10.1371/JOURNAL.PONE.0064145

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Europe PubMed Central

PubMed publication ID

4 August 2017

2013PLoSO...864145C

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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