(Q34732953)

4 August 2017

title

Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells (English)

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4 August 2017

main subject

endoplasmic reticulum

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Vardit Dror

1

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4 August 2017

Tatyana B Kalynyak

2

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4 August 2017

Yaryna Bychkivska

3

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4 August 2017

Matthew H Z Frey

4

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4 August 2017

May Tee

5

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4 August 2017

Kristin D Jeffrey

6

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4 August 2017

Vy Nguyen

7

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4 August 2017

Dan S Luciani

8

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4 August 2017

James D Johnson

9

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4 August 2017

language of work or name

English

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publication date

3 January 2008

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Journal of Biological Chemistry

4 August 2017

published in

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4 August 2017

volume

283

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4 August 2017

issue

15

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4 August 2017

page(s)

9909-9916

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beta-Cell death during progression to diabetes

4 August 2017

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Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

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Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6.

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Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation.

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Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis

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Identification of regulatory cis-acting elements for alternative splicing of presenilin 2 exon 5 under hypoxic stress conditions

21 January 2018

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Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression

21 January 2018

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21 January 2018

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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

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Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

21 January 2018

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Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.

21 January 2018

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Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis

21 January 2018

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Caspase-independent phosphatidylserine exposure during apoptosis of primary T lymphocytes

21 January 2018

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

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Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells

21 January 2018

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Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals

21 January 2018

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The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis

21 January 2018

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 January 2018

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Pancreatic organogenesis--developmental mechanisms and implications for therapy

21 January 2018

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Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

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Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

21 January 2018

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

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Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

21 January 2018

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gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.

21 January 2018

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Neuronal and glial calcium signaling in Alzheimer's disease

21 January 2018

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

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The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis

21 January 2018

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Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.

21 January 2018

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Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

21 January 2018

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Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation

21 January 2018

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PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

21 January 2018

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Mutations of presenilin genes in dilated cardiomyopathy and heart failure

21 January 2018

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Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710601200

Presenilin-1 is located in rat mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710601200

Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710601200

Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710601200

21 January 2018

Identifiers

DOI

10.1074/JBC.M710601200

1 reference

4 August 2017

1 reference