(Q34750643)

4 August 2017

1 reference

title

The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease (English)

1 reference

4 August 2017

0 references

George Perry

5

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Mark Anthony Smith

series ordinal

6

object named as

Mark A Smith

1 reference

4 August 2017

2

Craig S Atwood

1 reference

4 August 2017

Catherine A. Rottkamp

series ordinal

1

object named as

Catherine A Rottkamp

1 reference

4 August 2017

James A Joseph

3

1 reference

4 August 2017

Akihiko Nunomura

series ordinal

4

1 reference

4 August 2017

publication date

1 July 2002

1 reference

4 August 2017

number of pages

9

1 reference

inferred from page(s)

published in

Peptides

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4 August 2017

volume

23

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4 August 2017

issue

7

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4 August 2017

page(s)

1333-1341

1 reference

Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

4 August 2017

cites work

1 reference

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7 January 2021

Factors Affecting Pro- and Anti-Oxidant Properties of Fragments of the b-Protein Precursor (bPP): Implication for Alzheimer's Disease.

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7 January 2021

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.

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7 January 2021

Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease

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7 January 2021

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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7 January 2021

Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits

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7 January 2021

Vitamin E protects nerve cells from amyloid beta protein toxicity

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7 January 2021

Topography of Axonal Injury as Defined by Amyloid Precursor Protein and the Sector Scoring Method in Mild and Severe Closed Head Injury

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7 January 2021

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain

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7 January 2021

A beta (25-35) peptide displays H2O2-like reactivity towards aqueous Fe2+, nitroxide spin probes, and synaptosomal membrane proteins.

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7 January 2021

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

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7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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7 January 2021

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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7 January 2021

An analysis of the effects of Alzheimer's plaques on living neurons

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7 January 2021

Heat shock alters Alzheimer's beta amyloid precursor protein expression in human endothelial cells.

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Generation of amyloid beta protein from its precursor is sequence specific

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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7 January 2021

beta-Amyloid neurotoxicity: a discussion of in vitro findings

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7 January 2021

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

1 reference

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7 January 2021

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques.

1 reference

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7 January 2021

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides

1 reference

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7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

1 reference

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7 January 2021

Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Senile plaques as aberrant sprout-stimulating structures

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Molecular basis of Alzheimer's disease

1 reference

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7 January 2021

APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

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7 January 2021

Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils

1 reference

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7 January 2021

Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes.

1 reference

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7 January 2021

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

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7 January 2021

Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats

1 reference

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7 January 2021

Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

1 reference

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7 January 2021

The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models

1 reference

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

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7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

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7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Copernicus revisited: amyloid beta in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid fibril toxicity in Alzheimer's disease and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

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7 January 2021

Physiological levels of beta-amyloid peptide promote PC12 cell proliferation

1 reference

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7 January 2021

Deposition of amyloid beta protein in non-Alzheimer dementias: evidence for a neuronal origin of parenchymal deposits of beta protein in neurodegenerative disease.

1 reference

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7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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7 January 2021

Degenerative and protective signaling mechanisms in the neurofibrillary pathology of AD.

1 reference

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7 January 2021

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.

1 reference

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7 January 2021

Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli

1 reference

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7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus

1 reference

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7 January 2021

Cell cycle markers in the hippocampus in Alzheimer's disease.

1 reference

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7 January 2021

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions.

1 reference

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7 January 2021

Alzheimer's disease: a re-examination of the amyloid hypothesis

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7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

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7 January 2021

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment

1 reference

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7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells

1 reference

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7 January 2021

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7 January 2021

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7 January 2021

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

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7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The role of cell cycle-mediated events in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Mitotic neurons: a dogma succumbs

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7 January 2021

Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.

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7 January 2021

Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease

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7 January 2021

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Oxidative stress, antioxidants, and Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Redox-active iron mediates amyloid-beta toxicity

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Estrogen attenuates over-expression of beta-amyloid precursor protein messager RNA in an animal model of focal ischemia

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Effect of substance P and protein kinase inhibitors on beta-amyloid peptide-induced proliferation of cultured brain cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Secretion of the β‐Amyloid Precursor Proteina

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Arson. Tracking the culprit in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

ApoE as a prognostic factor for post–traumatic coma

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Trophic effects of substance P and beta-amyloid peptide on dibutyryl cyclic AMP-differentiated human leukemic (HL-60) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Rapid appearance of beta-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Mitotic mechanisms in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Beta-amyloid protein promotes neuritic branching in hippocampal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Cell cycle events in neurons. Proliferation or death?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Activation of oncogenic pathways in degenerating neurons in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Call for Elan to publish Alzheimer's trial details.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

Nerve inflammation halts trial for Alzheimer's drug.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900069-4

7 January 2021

10.1016/S0196-9781(02)00069-4

Identifiers

DOI

1 reference

4 August 2017

1 reference