(Q34982229)

English

Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21).

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Europe PubMed Central

PubMed publication ID

5 August 2017

Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

based on heuristic

inferred from title

B-cell lymphoma

1 reference

based on heuristic

inferred from title

diffuse large B-cell lymphoma

1 reference

based on heuristic

inferred from title

Francois X Claret

6

object named as

F X Claret

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

E Drakos

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

R R Singh

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

G Z Rassidakis

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

E Schlette

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

J Li

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

R J Ford

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

F Vega

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

L J Medeiros

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

publication date

11 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

856-867

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Targeting p53 to mitochondria for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Restoration of p53 function leads to tumour regression in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Modeling the therapeutic efficacy of p53 restoration in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Bcl2's flexible loop domain regulates p53 binding and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Molecular pathogenesis of follicular lymphoma: a cross talk of genetic and immunologic factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Phosphorylation of Bcl2 and regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Establishment and characterization of human B-cell lymphoma cell lines using B-cell growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

p53 mutations in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

8 July 2018

Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

Ceramide regulates cellular homeostasis via diverse stress signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094765

26 October 2018

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.28

21 January 2018

Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutation is associated with progression in follicular lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutations are associated with histologic transformation of follicular lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A limited role for TP53 mutation in the transformation of follicular lymphoma to diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21394100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2011.28

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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