(Q35022586)

5 August 2017

title

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor (English)

1 reference

5 August 2017

Joshua G DeKeyser

1

1 reference

5 August 2017

Elizabeth M Laurenzana

2

1 reference

5 August 2017

Eric C Peterson

3

1 reference

5 August 2017

Tao Chen

4

1 reference

5 August 2017

Curtis J Omiecinski

5

1 reference

5 August 2017

publication date

12 January 2011

1 reference

5 August 2017

published in

Toxicological Sciences

1 reference

5 August 2017

volume

120

1 reference

5 August 2017

issue

2

1 reference

5 August 2017

page(s)

381-391

1 reference

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

5 August 2017

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1 reference

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8 July 2018

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Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

8 July 2018

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Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men.

8 July 2018

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Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures

8 July 2018

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8 July 2018

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8 July 2018

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Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review

8 July 2018

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8 July 2018

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8 July 2018

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The environmental estrogen, nonylphenol, activates the constitutive androstane receptor

8 July 2018

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CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics

8 July 2018

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NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate

8 July 2018

1 reference

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

8 July 2018

1 reference

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Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

8 July 2018

1 reference

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Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment

8 July 2018

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Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure

8 July 2018

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8 July 2018

1 reference

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Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Induction of phase I, II and III drug metabolism/transport by xenobiotics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Alternatively spliced isoforms of the human constitutive androstane receptor

8 July 2018

1 reference

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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

8 July 2018

1 reference

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

8 July 2018

1 reference

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Structure validation by Calpha geometry: phi,psi and Cbeta deviation

8 July 2018

1 reference

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Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107492

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

8 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ394

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21227907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/TOXSCI/KFQ394

1 reference

5 August 2017

1 reference

5 August 2017

1 reference