(Q35056065)

6 August 2017

Modeling human neurological disorders with induced pluripotent stem cells (English)

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Human Induced Pluripotent Stem Cells

6 August 2017

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2

Hideyuki Okano

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6 August 2017

1

Yoichi Imaizumi

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PubMed ID

24286589

6 August 2017

language of work or name

English

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publication date

15 December 2013

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Journal of Neurochemistry

6 August 2017

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6 August 2017

129

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6 August 2017

3

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6 August 2017

388-399

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Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

6 August 2017

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Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

21 January 2018

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Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome

21 January 2018

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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

21 January 2018

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Induced pluripotent stem cells: the new patient?

21 January 2018

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Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease

21 January 2018

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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

21 January 2018

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Modelling schizophrenia using human induced pluripotent stem cells

21 January 2018

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Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

21 January 2018

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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

21 January 2018

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

21 January 2018

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Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient.

21 January 2018

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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

21 January 2018

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Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

21 January 2018

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Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling

21 January 2018

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Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

21 January 2018

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

21 January 2018

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Induced pluripotent stem cells from a spinal muscular atrophy patient

21 January 2018

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Drug screening for ALS using patient-specific induced pluripotent stem cells

21 January 2018

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Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

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Efficient derivation of functional floor plate tissue from human embryonic stem cells

21 January 2018

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Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

21 January 2018

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A human Dravet syndrome model from patient induced pluripotent stem cells

21 January 2018

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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

21 January 2018

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Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients

21 January 2018

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Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis

21 January 2018

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Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

21 January 2018

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Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

21 January 2018

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Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons

21 January 2018

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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells

21 January 2018

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Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

21 January 2018

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Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.

21 January 2018

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Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

21 January 2018

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Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

21 January 2018

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Specification of motoneurons from human embryonic stem cells.

21 January 2018

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Trisomy correction in Down syndrome induced pluripotent stem cells

21 January 2018

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Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

21 January 2018

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Signaling defects in iPSC-derived fragile X premutation neurons

21 January 2018

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Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

21 January 2018

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Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

21 January 2018

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Patient-derived stem cells: pathways to drug discovery for brain diseases

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

21 January 2018

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

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Modeling human disease with pluripotent stem cells: from genome association to function.

21 January 2018

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A TALE nuclease architecture for efficient genome editing

21 January 2018

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Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

21 January 2018

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L1 retrotransposition in neurons is modulated by MeCP2.

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

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Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy

21 January 2018

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Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells

21 January 2018

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Disease-specific induced pluripotent stem cells

21 January 2018

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Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

21 January 2018

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Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient.

21 January 2018

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Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells.

21 January 2018

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Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

21 January 2018

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Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

21 January 2018

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CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

21 January 2018

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The promise of induced pluripotent stem cells in research and therapy

21 January 2018

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

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Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia.

21 January 2018

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Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

21 January 2018

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21 January 2018

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Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

21 January 2018

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Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease.

21 January 2018

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Direct conversion of fibroblasts to functional neurons by defined factors

21 January 2018

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Deficits in human trisomy 21 iPSCs and neurons

21 January 2018

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

21 January 2018

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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

21 January 2018

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A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

21 January 2018

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Rapid single-step induction of functional neurons from human pluripotent stem cells

21 January 2018

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Generation of induced pluripotent stem cells using recombinant proteins

21 January 2018

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Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10821

Identifiers

DOI

10.1111/JNC.12625

1 reference

6 August 2017

1 reference

PubMed ID

24286589