(Q35097346)

6 August 2017

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title

Modelling brain diseases in mice: the challenges of design and analysis (English)

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6 August 2017

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Huda Y Zoghbi

2

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author name string

Kei Watase

series ordinal

1

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6 August 2017

1 April 2003

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6 August 2017

Nature Reviews Genetics

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6 August 2017

4

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6 August 2017

296-307

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6 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrg1045

6 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

31 March 2020

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

31 March 2020

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Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

31 March 2020

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Prions, peptides and protein misfolding

31 March 2020

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

31 March 2020

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alpha-Galactosidase A deficient mice: a model of Fabry disease

31 March 2020

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Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice

31 March 2020

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Gene therapy for Fabry disease

31 March 2020

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Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy.

31 March 2020

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Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy

31 March 2020

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Tools for targeted manipulation of the mouse genome

31 March 2020

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Conditional control of gene expression in the mouse

31 March 2020

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Application of magnetic resonance to animal models of cerebral ischemia.

31 March 2020

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Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

31 March 2020

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Compromised hemodynamic response in amyloid precursor protein transgenic mice.

31 March 2020

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Imaging physiologic dysfunction of individual hippocampal subregions in humans and genetically modified mice.

31 March 2020

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In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

31 March 2020

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Targeting alzheimer amyloid plaques in vivo

31 March 2020

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Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

31 March 2020

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Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

31 March 2020

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Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

31 March 2020

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Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

31 March 2020

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Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

31 March 2020

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

31 March 2020

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Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

31 March 2020

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Therapeutic effects of cystamine in a murine model of Huntington's disease.

31 March 2020

1 reference

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

31 March 2020

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A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice

31 March 2020

1 reference

Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations

31 March 2020

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List of transgenic and knockout mice: behavioral profiles

31 March 2020

1 reference

Long-term consequences of developmental exposure to aluminum in a suboptimal diet for growth and behavior of Swiss Webster mice

31 March 2020

1 reference

Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

31 March 2020

1 reference

Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

31 March 2020

1 reference

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

31 March 2020

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Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases

31 March 2020

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Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress

31 March 2020

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Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice

31 March 2020

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Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene

31 March 2020

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Assembly of CNS myelin in the absence of proteolipid protein

31 March 2020

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Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.

31 March 2020

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

31 March 2020

1 reference

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues

31 March 2020

1 reference

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRG1045

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6 August 2017

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PubMed ID

12671660