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Molecular subgroups of medulloblastoma
scientific article
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
title
Molecular subgroups of medulloblastoma
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
main subject
medulloblastoma
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author
Stefan M. Pfister
object named as
Stefan Pfister
series ordinal
3
0 references
Paul A Northcott
series ordinal
1
object named as
Paul A Northcott
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
Michael D. Taylor
series ordinal
4
object named as
Michael D Taylor
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
Adrian M Dubuc
series ordinal
2
object named as
Adrian M Dubuc
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
publication date
1 July 2012
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stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
published in
Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
volume
12
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
issue
7
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
page(s)
871-884
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
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MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
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9 July 2018
Mouse models of medulloblastoma
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Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
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Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology
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Rapid diagnosis of medulloblastoma molecular subgroups
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9 July 2018
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
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Histology predicts a favorable outcome in young children with desmoplastic medulloblastoma: a report from the children's oncology group.
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9 July 2018
The genetic landscape of the childhood cancer medulloblastoma
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Subtypes of medulloblastoma have distinct developmental origins
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9 July 2018
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
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Clinical experience with Hedgehog pathway inhibitors
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9 July 2018
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis
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9 July 2018
Medulloblastoma comprises four distinct molecular variants
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9 July 2018
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma
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9 July 2018
Pleiotropic role for MYCN in medulloblastoma.
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9 July 2018
The genetics of pediatric brain tumors
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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
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9 July 2018
Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years
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OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas
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Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization
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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
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9 July 2018
Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective
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9 July 2018
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
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9 July 2018
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
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9 July 2018
Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91.
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9 July 2018
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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9 July 2018
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
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9 July 2018
Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesis
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9 July 2018
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
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9 July 2018
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
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PubMed Central
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9 July 2018
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).
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9 July 2018
The origins of medulloblastoma subtypes
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9 July 2018
Subclass mapping: identifying common subtypes in independent disease data sets
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9 July 2018
The 2007 WHO classification of tumours of the central nervous system
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9 July 2018
Metagene projection for cross-platform, cross-species characterization of global transcriptional states
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9 July 2018
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
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9 July 2018
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
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9 July 2018
c-myc overexpression causes anaplasia in medulloblastoma
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9 July 2018
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee
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9 July 2018
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
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9 July 2018
Mutations in SUFU predispose to medulloblastoma
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PubMed Central
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9 July 2018
Prediction of central nervous system embryonal tumour outcome based on gene expression
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9 July 2018
Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review
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9 July 2018
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
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PubMed Central
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9 July 2018
Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
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PubMed Central
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9 July 2018
Medulloblastoma with extensive nodularity: a variant with favorable prognosis.
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PubMed Central
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9 July 2018
Altered neural cell fates and medulloblastoma in mouse patched mutants
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PubMed Central
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9 July 2018
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts
1 reference
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PubMed Central
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9 July 2018
N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification.
1 reference
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PubMed Central
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9 July 2018
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
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PubMed Central
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27 September 2018
Finding the perfect partner for medulloblastoma prognostication.
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27 September 2018
p53 expression predicts dismal outcome for medulloblastoma patients with metastatic disease
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PubMed Central
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27 September 2018
Adult medulloblastoma comprises three major molecular variants.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
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27 September 2018
Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation.
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27 September 2018
TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Gender affects survival for medulloblastoma only in older children and adults: a study from the Surveillance Epidemiology and End Results Registry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Loss of suppressor-of-fused function promotes tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Survival of adults treated for medulloblastoma using paediatric protocols.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Medulloblastoma with extensive nodularity: a variant occurring in the very young-clinicopathological and immunohistochemical study of four cases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Large-cell medulloblastomas. A distinct variant with highly aggressive behavior
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334443
retrieved
27 September 2018
Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22853794
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1586/ERN.12.66
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
PMCID
4334443
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
PubMed ID
22853794
1 reference
stated in
Europe PubMed Central
PubMed ID
22853794
retrieved
6 August 2017
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