(Q35126704)

English

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1 reference

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author name string

Hongling Zhao

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Frederick Bauzon

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Enguang Bi

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

J Jessica Yu

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Hao Fu

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Zhonglei Lu

6

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Jinhua Cui

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Hyungjun Jeon

8

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Xingxing Zang

9

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

B Hilda Ye

10

1 reference

Europe PubMed Central

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6 August 2017

Liang Zhu

11

1 reference

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6 August 2017

language of work or name

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publication date

12 January 2015

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Europe PubMed Central

PubMed publication ID

6 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

290

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

5797-5809

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Antitumor mechanisms when pRb and p53 are genetically inactivated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Clonal selection in the germinal centre by regulated proliferation and hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

The spleen in local and systemic regulation of immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

How T follicular helper cells and the germinal centre response change with age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

T follicular helper cell dynamics in germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Molecular regulation of stem cell quiescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Specific small molecule inhibitors of Skp2-mediated p27 degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Follicular helper CD4 T cells (TFH)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Requirement for cyclin D3 in germinal center formation and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Hematopoietic fingerprints: an expression database of stem cells and their progeny

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Molecular signatures of proliferation and quiescence in hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Immune regulation by CD40 and its ligand GP39.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

Effects of an Rb mutation in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

28 July 2018

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.625350

21 January 2018

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.625350

21 January 2018

Atheroma development in apolipoprotein E-null mice is not regulated by phosphorylation of p27(Kip1) on threonine 187.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.625350

21 January 2018

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.625350

21 January 2018

Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

27 September 2018

Unexpected expansions of CD8-bearing cells in old mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342489

27 September 2018

SnapShot: The Germinal Center Reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.625350

21 January 2018

Down-regulation of p27Kip1 expression is required for development and function of T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25583987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant

1 reference

https://pubmed.ncbi.nlm.nih.gov/25583987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.625350

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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