(Q35135602)

6 August 2017

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title

Does Rap1 deserve a bad Rap? (English)

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6 August 2017

Philip J S Stork

1

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6 August 2017

1 May 2003

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6 August 2017

9

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Trends in Biochemical Sciences

inferred from page(s)

published in

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6 August 2017

28

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6 August 2017

5

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6 August 2017

267-275

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Ras and relatives--job sharing and networking keep an old family together

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Rap1 signalling: adhering to new models

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Nerve growth factor activates persistent Rap1 signaling in endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Mechanism of the spatio-temporal regulation of Ras and Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

The role of Rap1 in integrin-mediated cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

A family of cAMP-binding proteins that directly activate Rap1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cyclic AMP-dependent activation of Rap1b

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3',5'-monophosphate effects on prolactin promoter activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Differential effects of cAMP in neurons and astrocytes. Role of B-raf

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Ras and Rap control AMPA receptor trafficking during synaptic plasticity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

Rap1 reverses transcriptional repression of TGF-beta type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900087-2

7 January 2021

10.1016/S0968-0004(03)00087-2

Identifiers

DOI

1 reference

release_yhfj2tv66ffdzdbvhzy3o5dwty

6 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yhfj2tv66ffdzdbvhzy3o5dwty

24 November 2022

mapped directly with Wikidata item

PubMed ID

12765839

1 reference

PubMed ID

12765839