(Q35138276)

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Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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based on heuristic

inferred from title

pancreatic cancer

1 reference

based on heuristic

inferred from title

Rakesh Srivastava

7

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Rakesh Srivastava

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Minzhao Huang

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Su-Ni Tang

2

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Europe PubMed Central

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12 March 2020

Ghanshyam Upadhyay

3

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Europe PubMed Central

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12 March 2020

Justin L Marsh

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Christopher P Jackman

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Sharmila Shankar

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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2 April 2014

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12 March 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

e92161

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

copyright license

Creative Commons Attribution 4.0 International

2 April 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment.

1 reference

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Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.

1 reference

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Cancer statistics, 2013

1 reference

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GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

1 reference

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Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway

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13 July 2018

Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal

1 reference

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Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells

1 reference

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13 July 2018

Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

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Hereditary pancreatic cancer: molecular bases and their application in diagnosis and clinical management: a guideline of the TTD group

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Cell intrinsic role of COX-2 in pancreatic cancer development

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Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment

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Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.

1 reference

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13 July 2018

Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms

1 reference

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13 July 2018

Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

1 reference

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13 July 2018

IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

13 July 2018

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

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Metastasis: new perspectives on an old problem

1 reference

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13 July 2018

Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

13 July 2018

Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

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Pancreatic cancer: understanding and overcoming chemoresistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

13 July 2018

PTEN loss accelerates KrasG12D-induced pancreatic cancer development

1 reference

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13 July 2018

The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition

1 reference

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13 July 2018

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

13 July 2018

Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973629

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Hedgehog signaling and gastrointestinal cancer

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Pancreatic cancer: pathobiology, treatment options, and drug delivery

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The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.

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Hedgehog signalling: emerging evidence for non-canonical pathways

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Hedgehog: functions and mechanisms

1 reference

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Tumor metastasis: mechanistic insights and clinical challenges

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Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

1 reference

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1 reference

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1 reference

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Angiogenesis and proteins of the hemostatic system

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24694877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0092161

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2014PLoSO...992161H

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694877%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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