(Q35143036)

6 August 2017

Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin (English)

1 reference

6 August 2017

1 reference

3

Gunda I Georg

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6 August 2017

Mohan L Gupta

1

1 reference

6 August 2017

Claudia J Bode

series ordinal

2

1 reference

6 August 2017

Richard H Himes

series ordinal

4

1 reference

6 August 2017

language of work or name

English

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publication date

9 May 2003

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

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6 August 2017

100

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6 August 2017

6394-6397

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6 August 2017

11

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Raster3D Version 2.0. A program for photorealistic molecular graphics

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

The solid state, solution and tubulin-bound conformations of agents that promote microtubule stabilization

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

The chemistry of taxol and related taxoids

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Refined structure of alpha beta-tubulin at 3.5 A resolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Conformation of microtubule-bound paclitaxel determined by fluorescence spectroscopy and REDOR NMR.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

A common pharmacophore for cytotoxic natural products that stabilize microtubules

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Structure of the alpha beta tubulin dimer by electron crystallography

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Taxol binds to polymerized tubulin in vitro

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Relationships between the structure of taxol analogs and their antimitotic activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Yeast proteins associated with microtubules in vitro and in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164457

Predominant labeling of beta- over alpha-tubulin from porcine brain by a photoactivatable taxoid derivative.

13 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Mutagenesis of beta-tubulin cysteine residues in Saccharomyces cerevisiae: mutation of cysteine 354 results in cold-stable microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Purification and biochemical characterization of tubulin from the budding yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

The interaction of baccatin III with the taxol binding site of microtubules determined by a homogeneous assay with fluorescent taxoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Synthesis of a photoaffinity taxol analogue and its use in labeling tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

Characterization of the Taxol Binding Site on the Microtubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

A pH- and temperature-dependent cycling method that doubles the yield of microtubule protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

The effects of dimethyl sulfoxide on the kinetics of tubulin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1131967100

21 January 2018

Identifiers

DOI

10.1073/PNAS.1131967100

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference