(Q35146563)

6 August 2017

The INK4a/ARF locus and melanoma (English)

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6 August 2017

1

1 reference

6 August 2017

2

Lynda Chin

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PubMed ID

12789286

6 August 2017

language of work or name

English

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publication date

1 May 2003

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6 August 2017

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6 August 2017

22

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6 August 2017

20

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6 August 2017

3092-3098

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206461

6 August 2017

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cites work

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Dual inactivation of RB and p53 pathways in RAS-induced melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Photocarcinogenesis in human adult skin grafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Cdc25 cell-cycle phosphatase as a target of c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The pathogenesis of melanoma induced by ultraviolet radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Sun exposure and melanocytic naevi in young Australian children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Identification of CDK4 as a target of c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Germline p16 mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A cell cycle regulator potentially involved in genesis of many tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Twist is a potential oncogene that inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

G2 phase cell cycle arrest in human skin following UV irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The expression of p16(INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

p16(MTS-1/CDKN2/INK4a) in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

p16INK4A participates in a G1 arrest checkpoint in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The INK4A/ARF locus and its two gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Invasive melanoma in Cdk4-targeted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

p16INK4 mediates contact-inhibition of growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Cutaneous melanoma and sunburns in childhood in a Southern European population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

Neonatal sunburn and melanoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

inferred from DOI database lookup

7 January 2021

based on heuristic

Expression of cell cycle regulators in human cutaneous malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

inferred from DOI database lookup

7 January 2021

based on heuristic

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206461

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1206461

1 reference

6 August 2017

1 reference

PubMed ID

12789286