(Q35150284)

6 August 2017

title

Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity (English)

1 reference

6 August 2017

4

Marcus Kaul

1 reference

6 August 2017

Yunyi Kang

1

1 reference

6 August 2017

Stefano Tiziani

series ordinal

2

1 reference

6 August 2017

Goonho Park

series ordinal

3

1 reference

6 August 2017

Giovanni Paternostro

series ordinal

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

17 April 2014

1 reference

6 August 2017

published in

Nature Communications

1 reference

6 August 2017

volume

5

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6 August 2017

page(s)

3672

1 reference

H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling

6 August 2017

cites work

1 reference

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Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation

28 July 2018

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Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species

28 July 2018

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Oxidative stress in neurodegeneration: cause or consequence?

28 July 2018

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28 July 2018

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Oxytosis: A novel form of programmed cell death

28 July 2018

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28 July 2018

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28 July 2018

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Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

28 July 2018

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28 July 2018

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Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.

28 July 2018

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28 July 2018

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Oxidative stress, glutamate, and neurodegenerative disorders

28 July 2018

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The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme

28 July 2018

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Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

28 July 2018

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Glutamate neurotoxicity and diseases of the nervous system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

PI3Kγ contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

AIF depletion provides neuroprotection through a preconditioning effect.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

MetaboLab--advanced NMR data processing and analysis for metabolomics

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Using isoform-specific inhibitors to target lipid kinases.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Insulin-like growth factor 1 prevents neuronal cell death induced by corticosterone through activation of the PI3k/Akt pathway

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Transient phosphatidylinositol 3-kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal-regulated kinase activation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Regional membrane phospholipid alterations in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

The role of monoamine metabolism in oxidative glutamate toxicity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128233

Exchange of cystine and glutamate across plasma membrane of human fibroblasts

27 September 2018

1 reference

12 December 2020

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

12 December 2020

Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells

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12 December 2020

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

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12 December 2020

Identifiers

DOI

10.1038/NCOMMS4672

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference