(Q35162796)

English

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.

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scholarly article

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Europe PubMed Central

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24 February 2020

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway (English)

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24 February 2020

cerebrospinal fluid

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2

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24 February 2020

Martin Samuelsson

9

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24 February 2020

Camilla I Svensson

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24 February 2020

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24 February 2020

5

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Funda Orhan

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24 February 2020

Magdalena E Kegel

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Magdalena E Kegel

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24 February 2020

Lilly Schwieler

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Lilly Schwieler

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24 February 2020

16

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Göran Engberg

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24 February 2020

author name string

Elisabeth Skogh

3

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24 February 2020

Sally Abdelmoaty

6

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24 February 2020

Anja Finn

7

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24 February 2020

Maria Bhat

8

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24 February 2020

Kristina Lundberg

10

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24 February 2020

Marja-Liisa Dahl

11

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24 February 2020

Carl Sellgren

12

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24 February 2020

Ina Schuppe-Koistinen

13

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24 February 2020

publication date

1 March 2015

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24 February 2020

Journal of Psychiatry & Neuroscience

1 reference

Europe PubMed Central

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24 February 2020

40

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24 February 2020

2

1 reference

Europe PubMed Central

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24 February 2020

126-133

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25455350%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

A comprehensive family-based replication study of schizophrenia genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Kynurenines in the mammalian brain: when physiology meets pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

The kynurenine system and immunoregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Activation of brain interleukin-1beta in schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Neuroinflammation in schizophrenia-related psychosis: a PET study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Are some cases of psychosis caused by microbial agents? A review of the evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Elevations of endogenous kynurenic acid produce spatial working memory deficits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

28 July 2018

Reduction of brain kynurenic acid improves cognitive function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Proinflammatory and "resiliency" proteins in the CSF of patients with major depression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and N-desmethylolanzapine in human serum and cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Effects of olanzapine on plasma levels of catecholamine metabolites, cytokines, and brain-derived neurotrophic factor in schizophrenic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: a normative study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Endogenous kynurenic acid disrupts prepulse inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Increased cortical kynurenate content in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354818

27 September 2018

Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics

1 reference

https://pubmed.ncbi.nlm.nih.gov/25455350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High correlation between serum and cerebrospinal fluid olanzapine concentrations in patients with schizophrenia or schizoaffective disorder medicating with oral olanzapine as the only antipsychotic drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/25455350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated interleukin-6 in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25455350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype

1 reference

https://pubmed.ncbi.nlm.nih.gov/25455350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1503/JPN.140126

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25455350%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25455350%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25455350%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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