(Q35182662)

7 August 2017

Mast cell secretory granules: armed for battle (English)

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7 August 2017

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Sara Wernersson

1

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Gunnar Pejler

series ordinal

2

object named as

Gunnar Pejler

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7 August 2017

6 June 2014

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Nature Reviews Immunology

7 August 2017

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7 August 2017

14

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7 August 2017

7

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7 August 2017

478-494

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Developmental origin and functional specialization of mast cell subsets

7 August 2017

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Mast cells in the development of adaptive immune responses

21 January 2018

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Mast-cell responses to pathogens.

21 January 2018

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Innate immunity and its regulation by mast cells

21 January 2018

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Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

21 January 2018

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Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

21 January 2018

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Widespread immunological functions of mast cells: fact or fiction?

21 January 2018

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New models for analyzing mast cell functions in vivo

21 January 2018

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Sorting and storage during secretory granule biogenesis: looking backward and looking forward

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Mast cell proteoglycans

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Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

21 January 2018

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Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion

21 January 2018

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Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells

21 January 2018

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Ultrastructural studies of human basophils and mast cells

21 January 2018

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Differences in the volume distributions of human lung mast cell granules and lipid bodies: evidence that the size of these organelles is regulated by distinct mechanisms

21 January 2018

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Maturation of rat mast cells. An electron microscope study

21 January 2018

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Regulation of secretory granule size by the precise generation and fusion of unit granules

21 January 2018

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Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.

21 January 2018

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Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis

21 January 2018

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Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size

21 January 2018

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Efficient sorting of TNF-alpha to rodent mast cell granules is dependent on N-linked glycosylation.

21 January 2018

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A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components

21 January 2018

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Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells.

21 January 2018

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Transport of histamine by vesicular monoamine transporter-2.

21 January 2018

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Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan

21 January 2018

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Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand

21 January 2018

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Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases

21 January 2018

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Plasma extravasation induced by dietary supplemented histamine in histamine-free mice

21 January 2018

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TNF trafficking to human mast cell granules: mature chain-dependent endocytosis

21 January 2018

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Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

21 January 2018

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Serglycin is essential for maturation of mast cell secretory granule

21 January 2018

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Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

21 January 2018

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Heparin is essential for the storage of specific granule proteases in mast cells

21 January 2018

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Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin

21 January 2018

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Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast

21 January 2018

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Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes

21 January 2018

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Mice lacking histidine decarboxylase exhibit abnormal mast cells

21 January 2018

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Polyamines are present in mast cell secretory granules and are important for granule homeostasis

21 January 2018

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Distorted secretory granule composition in mast cells with multiple protease deficiency

21 January 2018

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Loss of histochemical identity in mast cells lacking carboxypeptidase A.

21 January 2018

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The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.

21 January 2018

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Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice

21 January 2018

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A role for cathepsin E in the processing of mast-cell carboxypeptidase A.

21 January 2018

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Mast cell procarboxypeptidase A. Molecular modeling and biochemical characterization of its processing within secretory granules

21 January 2018

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Processing of human protryptase in mast cells involves cathepsins L, B, and C.

21 January 2018

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New insights on mast cell activation via the high affinity receptor for IgE

21 January 2018

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The SNARE Machinery in Mast Cell Secretion

21 January 2018

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VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways

21 January 2018

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Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells

21 January 2018

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Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation

21 January 2018

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Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment

21 January 2018

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Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells

21 January 2018

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Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process

21 January 2018

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Rab27b regulates mast cell granule dynamics and secretion

21 January 2018

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Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells

21 January 2018

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The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis

21 January 2018

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Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

21 January 2018

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Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

21 January 2018

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Impact of actin rearrangement and degranulation on the membrane structure of primary mast cells: a combined atomic force and laser scanning confocal microscopy investigation

21 January 2018

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Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b

21 January 2018

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Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents

21 January 2018

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21 January 2018

Allergic host defences

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Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1.

21 January 2018

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The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover

21 January 2018

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Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection

21 January 2018

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The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections

21 January 2018

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Mast cell-specific Cre/loxP-mediated recombination in vivo

21 January 2018

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Pathophysiologic role of histamine: evidence clarified by histidine decarboxylase gene knockout mice

21 January 2018

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Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo

21 January 2018

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Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

21 January 2018

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Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis

21 January 2018

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Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions

21 January 2018

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Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation

21 January 2018

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Essential role for mast cell tryptase in acute experimental colitis

21 January 2018

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Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution

21 January 2018

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Interactions of mast cell tryptase with thrombin receptors and PAR-2.

21 January 2018

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Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen

21 January 2018

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Mast cells disrupt epithelial barrier function during enteric nematode infection

21 January 2018

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Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism

21 January 2018

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Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid

21 January 2018

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Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

21 January 2018

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Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

21 January 2018

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Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G.

21 January 2018

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Proteolytic activation of alternative CCR1 ligands in inflammation

21 January 2018

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Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo

21 January 2018

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Mast cell granule heparin proteoglycan induces lacunae in confluent endothelial cell monolayers

21 January 2018

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Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation

21 January 2018

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Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation.

21 January 2018

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Mast cells can promote the development of multiple features of chronic asthma in mice

21 January 2018

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Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

21 January 2018

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Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.

21 January 2018

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Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4.

21 January 2018

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Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4.

21 January 2018

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Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines

21 January 2018

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Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

21 January 2018

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Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation

21 January 2018

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Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.

21 January 2018

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Mast cells can enhance resistance to snake and honeybee venoms

21 January 2018

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Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

21 January 2018

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Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin

21 January 2018

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The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis

21 January 2018

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IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

21 January 2018

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Accelerated clearance of Escherichia coli in experimental peritonitis of histamine-deficient mice

21 January 2018

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Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1.

21 January 2018

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Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid

21 January 2018

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Mast cells: a cellular link between autoantibodies and inflammatory arthritis

21 January 2018

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Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis

21 January 2018

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Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis

21 January 2018

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The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.

21 January 2018

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Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes

21 January 2018

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Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis

21 January 2018

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Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase

21 January 2018

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A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2.

21 January 2018

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Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens

21 January 2018

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Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction

21 January 2018

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Human mast cell beta-tryptase is a gelatinase

21 January 2018

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Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis

21 January 2018

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Mast cell chymase and tryptase during tissue turnover: analysis on in vitro mitogenesis of fibroblasts and keratinocytes and alterations in cutaneous scars

21 January 2018

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Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet

21 January 2018

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Mast cell-derived particles deliver peripheral signals to remote lymph nodes

21 January 2018

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Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

21 January 2018

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Central nervous system neurons acquire mast cell products via transgranulation

21 January 2018

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Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma

21 January 2018

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Biological implications of preformed mast cell mediators

21 January 2018

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Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways

21 January 2018

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Catecholamines in murine bone marrow derived mast cells

21 January 2018

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Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin.

21 January 2018

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Interleukin 4 is localized to and released by human mast cells

21 January 2018

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Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206.

21 January 2018

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Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression

21 January 2018

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Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase

21 January 2018

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Mast cells synthesize, store, and release nerve growth factor

21 January 2018

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An enzyme in mast cells with properties like chymotrypsin

21 January 2018

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Proteolytic enzymes of rat liver mitochondria. Evidence for a mast cell origin

21 January 2018

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Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha

21 January 2018

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Active caspase-3 is stored within secretory compartments of viable mast cells.

21 January 2018

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Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner

21 January 2018

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ADAMTS: novel proteases expressed by activated mast cells

21 January 2018

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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

21 January 2018

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Mast cells: a unique source of renin

21 January 2018

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Rat Basophilic Leukemia Cells Express Syntaxin-3 and VAMP-7 in Granule Membranes

21 January 2018

1 reference

Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis

21 January 2018

2 references

21 January 2018

12 December 2020

Function of the t-SNARE SNAP-23 and secretory carrier membrane proteins (SCAMPs) in exocytosis in mast cells

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A granular variant of CD63 is a regulator of repeated human mast cell degranulation

21 January 2018

1 reference

Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis.

21 January 2018

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Decoding the regulation of mast cell exocytosis by networks of Rab GTPases

21 January 2018

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Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation

21 January 2018

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Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin

21 January 2018

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Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse.

21 January 2018

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Transgenic study of the function of chymase in heart remodeling

21 January 2018

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Synthesis of serotonin by a second tryptophan hydroxylase isoform

21 January 2018

1 reference

Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE.

21 January 2018

1 reference

A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice

21 January 2018

1 reference

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

21 January 2018

2 references

21 January 2018

12 December 2020

Critical protective role of mast cells in a model of acute septic peritonitis

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Histochemical Demonstration of a Species-Specific Trypsin-like Enzyme in Mast Cells

21 January 2018

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21 January 2018

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Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

31 March 2020

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Differential release of serotonin and histamine from mast cells

31 March 2020

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Beige mouse mast cells generated in vitro: ultrastructural analysis of maturation induced by sodium butyrate and of IgE-mediated, antigen-dependent degranulation

31 March 2020

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Effect of age on mast cell granules

31 March 2020

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Recovery of rat mast cells after secretion: a morphometric study

31 March 2020

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Uptake and turnover of dopamine in rat mast cells studied by cytofluorometry and high performance liquid chromatography

31 March 2020

1 reference

Eosinophil peroxidase accounts for most if not all of the peroxidase activity associated with isolated rat peritoneal mast cells

31 March 2020

1 reference

Histamine synthesis is required for granule maturation in murine mast cells.

31 March 2020

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Serotonin content is elevated in the immune cells of histidine decarboxylase gene knock-out (HDCKO) mice. Focus on mast cells

31 March 2020

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New developments in FcepsilonRI regulation, function and inhibition

31 March 2020

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Inhaled tryptase causes bronchoconstriction in sheep via histamine release

31 March 2020

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Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism

31 March 2020

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Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment

31 March 2020

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Neutrophil elastase depends on serglycin proteoglycan for localization in granules

31 March 2020

1 reference

Enzymes of the mast cell granule

31 March 2020

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Histamine in tissue mast cells

31 March 2020

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Serotonin and histamine in mast cells

31 March 2020

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5-Hydroxytryptamine in mast cells.

31 March 2020

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Human mast cells are capable of serotonin synthesis and release

31 March 2020

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Human mast cells express stem cell factor

31 March 2020

2 references

31 March 2020

12 December 2020

SNAP-23 and syntaxin-3 are required for chemokine release by mature human mast cells

1 reference

Crucial role for autophagy in degranulation of mast cells

31 March 2020

1 reference

Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B

31 March 2020

1 reference

12 December 2020

An immunocytochemical approach to the demonstration of intracellular processing of mast cell carboxypeptidase

1 reference

12 December 2020

Degranulating mast cells secrete an endoglycosidase that degrades heparan sulfate in subendothelial extracellular matrix.

1 reference

12 December 2020

The lysosomal protease cathepsin D is efficiently sorted to and secreted from regulated secretory compartments in the rat basophilic/mast cell line RBL.

1 reference

12 December 2020

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation

1 reference

12 December 2020

Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.

1 reference

12 December 2020

Defective cytoplasmic granule formation. I. Abnormalities affecting tissue mast cells and pancreatic acinar cells of beige mice

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12 December 2020

Studies on the growth of mast cells in rats. Changes in granule size between 1 and 6 months

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12 December 2020

Serine proteinases are regionally segregated within mast cell granules

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12 December 2020

Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells.

1 reference

12 December 2020

Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases

1 reference

12 December 2020

Sequestration of eosinophil major basic protein in human mast cells

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12 December 2020

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart

1 reference

12 December 2020

Human cutaneous mast cells express basic fibroblast growth factor.

1 reference

12 December 2020

Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6.

1 reference

12 December 2020

Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells

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12 December 2020

Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3690

1 reference

7 August 2017

1 reference

PubMed ID

24903914