(Q35238017)

English

A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells

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scholarly article

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Europe PubMed Central

PubMed publication ID

7 August 2017

A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

3

object named as

Michele Vitolo

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

Hui-Fang Li

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Adam Keeton

2

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Europe PubMed Central

PubMed publication ID

7 August 2017

Clinton Maddox

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Lynn Rasmussen

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Judith Hobrath

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

E Lucille White

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Ben Ho Park

8

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Gary A Piazza

9

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Jung-Sik Kim

10

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Todd Waldman

11

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Europe PubMed Central

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7 August 2017

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publication date

18 February 2011

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Europe PubMed Central

PubMed publication ID

7 August 2017

Journal of Biomolecular Screening

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Europe PubMed Central

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7 August 2017

16

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Europe PubMed Central

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7 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

383-393

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Tenets of PTEN tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Human somatic cell gene targeting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Genetic knockouts and knockins in human somatic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Alternative statistical parameter for high-throughput screening assay quality assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Validating cancer drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

The concept of synthetic lethality in the context of anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Human cancer, PTEN and the PI-3 kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381441

13 July 2018

Why is cancer drug discovery so difficult?

1 reference

https://api.crossref.org/works/10.1177%2F1087057110397357

21 January 2018

Identifiers

10.1177/1087057110397357

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

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