(Q35326185)

7 August 2017

title

Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation (English)

1 reference

autosomal dominant polycystic kidney disease

7 August 2017

main subject

0 references

autosomal dominant polycystic kidney

1 reference

Anh-Nguyet T Nguyen

1

1 reference

7 August 2017

Kyle Jansson

2

1 reference

7 August 2017

Gladis Sánchez

3

1 reference

7 August 2017

Madhulika Sharma

4

1 reference

7 August 2017

Gail A Reif

5

1 reference

7 August 2017

Darren P Wallace

6

1 reference

7 August 2017

Gustavo Blanco

7

1 reference

7 August 2017

publication date

22 June 2011

1 reference

American Journal of Physiology - Renal Physiology

7 August 2017

published in

1 reference

7 August 2017

volume

301

1 reference

7 August 2017

issue

4

1 reference

7 August 2017

page(s)

F897-906

1 reference

c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation

7 August 2017

cites work

1 reference

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27 July 2018

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Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

27 July 2018

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Clinical practice. Autosomal dominant polycystic kidney disease

27 July 2018

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Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1

27 July 2018

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Src inhibition ameliorates polycystic kidney disease

27 July 2018

1 reference

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p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels

27 July 2018

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Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells

27 July 2018

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27 July 2018

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New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target

27 July 2018

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27 July 2018

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Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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Molecular pathogenesis of ADPKD: the polycystin complex gets complex

27 July 2018

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Polycystic kidney disease: new understanding in the pathogenesis

27 July 2018

1 reference

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Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease

27 July 2018

1 reference

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Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function

27 July 2018

1 reference

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Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase

27 July 2018

1 reference

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27 July 2018

1 reference

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

27 July 2018

1 reference

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The genetics and physiology of polycystic kidney disease

27 July 2018

1 reference

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Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control

27 July 2018

1 reference

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Ouabain-induced cell proliferation in cultured rat astrocytes.

27 July 2018

1 reference

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Chloride and fluid secretion by cultured human polycystic kidney cells

27 July 2018

1 reference

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A cytoplasmic region of the Na,K-ATPase alpha-subunit is necessary for specific alpha/alpha association

27 July 2018

1 reference

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27 July 2018

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Identification of a pool of non-pumping Na/K-ATPase

26 September 2018

1 reference

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26 September 2018

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Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

The pathogenesis of autosomal dominant polycystic kidney disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

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26 September 2018

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Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer

26 September 2018

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Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Low concentrations of ouabain activate vascular smooth muscle cell proliferation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Positive inotropic effect of ouabain on isolated heart is accompanied by activation of signal pathways that link Na+/K+-ATPase to ERK1/2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Endogenous cardiac glycosides, a new class of steroid hormones

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

The cellular mechanism of action of cardiotonic steroids: a new hypothesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191809

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21697238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MEK inhibition holds promise for polycystic kidney disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21697238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPRENAL.00095.2011

1 reference

7 August 2017

1 reference

7 August 2017

1 reference