(Q35351594)

7 August 2017

title

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region (English)

1 reference

7 August 2017

7

Ruth Nussinov

1 reference

7 August 2017

1

Hyunbum Jang

1 reference

7 August 2017

2

Sherwin J Abraham

1 reference

7 August 2017

3

Tanmay S Chavan

1 reference

7 August 2017

5

Lyuba Khavrutskii

1 reference

7 August 2017

6

Nadya I Tarasova

1 reference

7 August 2017

8

Vadim Gaponenko

1 reference

7 August 2017

Ben Hitchinson

4

1 reference

7 August 2017

language of work or name

English

0 references

publication date

24 February 2015

1 reference

Journal of Biological Chemistry

7 August 2017

published in

1 reference

7 August 2017

volume

290

1 reference

7 August 2017

issue

15

1 reference

7 August 2017

page(s)

9465-9477

1 reference

Dynamic multiprotein assemblies shape the spatial structure of cell signaling

7 August 2017

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1 reference

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Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

27 July 2018

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Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth

27 July 2018

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Mechanism of membrane permeation induced by synthetic β-hairpin peptides

27 July 2018

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Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment

27 July 2018

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The spatial structure of cell signaling systems

27 July 2018

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Lessons from computer simulations of Ras proteins in solution and in membrane

27 July 2018

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

27 July 2018

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27 July 2018

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Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

27 July 2018

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Raf inhibitors target ras spatiotemporal dynamics

27 July 2018

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All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

27 July 2018

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Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

27 July 2018

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Regulating the regulator: post-translational modification of RAS

27 July 2018

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A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy

27 July 2018

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Salirasib in the treatment of pancreatic cancer

27 July 2018

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Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies

27 July 2018

1 reference

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Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

27 July 2018

1 reference

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Ras membrane orientation and nanodomain localization generate isoform diversity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

27 July 2018

1 reference

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Protein lipid modifications in signaling and subcellular targeting

27 July 2018

1 reference

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Targeting the mevalonate pathway for improved anticancer therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Electrostatic interactions positively regulate K-Ras nanocluster formation and function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Inhibitors of chronically active ras: potential for treatment of human malignancies.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

A novel switch region regulates H-ras membrane orientation and signal output

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Interactions of Ras proteins with the plasma membrane and their roles in signaling.

27 July 2018

1 reference

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Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids--More than just membrane anchoring

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Trafficking and signaling by fatty-acylated and prenylated proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Nonconventional trafficking of Ras associated with Ras signal organization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Compartmentalized Ras/MAPK signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.

27 July 2018

1 reference

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Scalable molecular dynamics with NAMD

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

K-ras as a target for cancer therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

How environment supports a state: molecular dynamics simulations of two states in bacteriorhodopsin suggest lipid and water compensation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Investigation of temperature-induced phase transitions in DOPC and DPPC phospholipid bilayers using temperature-controlled scanning force microscopy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Model systems, lipid rafts, and cell membranes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Structure and fluctuations of charged phosphatidylserine bilayers in the absence of salt

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Prenylation inhibitors: a novel class of antiviral agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Lipid rafts: bringing order to chaos

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Phospholipids undergo hop diffusion in compartmentalized cell membrane

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Lipid rafts reconstituted in model membranes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

The importance of being K-Ras

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Molecular dynamics simulation of the gramicidin channel in a phospholipid bilayer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Protein prenylation: more than just glue?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Oligomerization and nanocluster organization render specificity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.

26 September 2018

1 reference

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Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Expression, purification, and characterization of soluble K-Ras4B for structural analysis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Electrical properties of plasma membrane modulate subcellular distribution of K-Ras.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Current status and progresses made in malaria chemotherapy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Insertion of lipidated Ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS).

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Cholera toxin B-subunit prevents activation and proliferation of human CD4+ T cells by activation of a neutral sphingomyelinase in lipid rafts.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4392252

Which Ras rides the raft?

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.620724

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.620724

Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.620724

Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange

21 January 2018

1 reference

12 December 2020

K-ras is essential for the development of the mouse embryo

1 reference

12 December 2020

Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane

1 reference

12 December 2020

Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains

1 reference

12 December 2020

Compartmentalization of Ras proteins

1 reference

12 December 2020

Structure, energetics, and dynamics of lipid-protein interactions: A molecular dynamics study of the gramicidin A channel in a DMPC bilayer

1 reference

12 December 2020

KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.620724

1 reference

7 August 2017

1 reference

7 August 2017

1 reference