(Q35397776)

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Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

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Europe PubMed Central

Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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protein-protein interaction

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

object named as

Kamyar Hadian

2

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author name string

Sheraz Gul

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

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publication date

6 November 2014

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Expert Opinion on Drug Discovery

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

1393-1404

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Identifying druggable disease-modifying gene products

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Protein-protein interactions in receptor activation and intracellular signalling

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Principles of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

How many drug targets are there?

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Discovery of small molecule cancer drugs: successes, challenges and opportunities

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Structural biology and drug discovery for protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Drugging the p53 pathway: understanding the route to clinical efficacy

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 reference

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21 January 2018

Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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21 January 2018

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

High-throughput screening assays to discover small-molecule inhibitors of protein interactions.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Impact of high-throughput screening in biomedical research

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

How were new medicines discovered?

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Phenotypic vs. target-based drug discovery for first-in-class medicines

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Fragment-based drug discovery using NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A high-throughput screen for aggregation-based inhibition in a large compound library

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Direct measurement of protein binding energetics by isothermal titration calorimetry

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Biosensor-surface plasmon resonance methods for quantitative analysis of biomolecular interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Label-free, real-time interaction and adsorption analysis 1: surface plasmon resonance

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Methods for the detection and analysis of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Discovery of selective small-molecule CD80 inhibitors.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Label-free detection with surface plasmon resonance imaging

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

SPR imaging for high throughput, label-free interaction analysis

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Protein-binding assays in biological liquids using microscale thermophoresis

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Label-free microscale thermophoresis discriminates sites and affinity of protein-ligand binding

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Molecular interaction studies using microscale thermophoresis

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A structural perspective on protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

TROSY NMR spectroscopy of large soluble proteins

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Isotope labeling and segmental labeling of larger RNAs for NMR structural studies

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

NMR-based screening in drug discovery

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

1 reference

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21 January 2018

The use of AlphaScreen technology in HTS: current status

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Fluorescence polarization: past, present and future

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Fluorescence polarization assays in small molecule screening

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

The use of FRET imaging microscopy to detect protein-protein interactions and protein conformational changes in vivo

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Improving FRET dynamic range with bright green and red fluorescent proteins

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

The BRET technology and its application to screening assays

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Using BRET to study chemical compound-induced disruptions of the p53-HDM2 interactions in live cells

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Bimolecular fluorescence complementation (BiFC): a 5-year update and future perspectives

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Direct observation of individual endogenous protein complexes in situ by proximity ligation

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Proximity ligation assays: a recent addition to the proteomics toolbox

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Isolation of proteins and protein complexes by immunoprecipitation

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Assessing the druggability of protein-protein interactions by a supervised machine-learning method

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Dr. PIAS 2.0: an update of a database of predicted druggable protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

An orthosteric inhibitor of the Ras-Sos interaction

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Disrupting the Rb-Raf-1 interaction: a potential therapeutic target for cancer

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Selective inhibition of BET bromodomains

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Suppression of inflammation by a synthetic histone mimic

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small-molecule inhibition of TNF-alpha

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Effective and specific inhibition of the CD40-CD154 costimulatory interaction by a naphthalenesulphonic acid derivative

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Small-molecule dimerization inhibitors of wild-type and mutant HIV protease: a focused library approach

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Live-cell assay for simultaneous monitoring of expression and interaction of proteins.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.954544

21 January 2018

MK-383 (L-700,462), a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist, is active in man

1 reference

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21 January 2018

Identifiers

10.1517/17460441.2014.954544

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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