(Q35563647)

8 August 2017

title

Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model (English)

1 reference

8 August 2017

1

Y Liang

1 reference

8 August 2017

H Gao

2

1 reference

8 August 2017

S-Y Lin

3

1 reference

8 August 2017

J A Goss

4

1 reference

8 August 2017

C Du

5

1 reference

8 August 2017

K Li

6

1 reference

8 August 2017

language of work or name

English

0 references

publication date

3 November 2014

1 reference

8 August 2017

1 reference

8 August 2017

volume

34

1 reference

8 August 2017

issue

33

1 reference

8 August 2017

page(s)

4368-4378

1 reference

Emerging roles of MCPH1: expedition from primary microcephaly to cancer

8 August 2017

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27 July 2018

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Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma

27 July 2018

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Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex

27 July 2018

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MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway

27 July 2018

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SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation

27 July 2018

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ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival

27 July 2018

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MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification.

27 July 2018

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Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation

27 July 2018

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Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression

27 July 2018

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BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice

27 July 2018

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Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair

27 July 2018

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Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

27 July 2018

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BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

27 July 2018

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14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

27 July 2018

1 reference

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NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment

27 July 2018

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27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer

27 July 2018

1 reference

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p53: guardian of the genome and policeman of the oncogenes.

27 July 2018

1 reference

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Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

DNA damage-induced cell death by apoptosis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

X chromosomal abnormalities in basal-like human breast cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Molecular genetics of T cell development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

The BRCT Domain Is a Phospho-Protein Binding Domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

27 July 2018

1 reference

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Mechanism and regulation of human non-homologous DNA end-joining

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Loss of p53 and centrosome hyperamplification.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Mutations of mitotic checkpoint genes in human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Identification of the breast cancer susceptibility gene BRCA2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

MCPH1 Protein Expression in Normal and Neoplastic Lung Tissues.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Frequent alterations of MCPH1 and ATM are associated with primary breast carcinoma: clinical and prognostic implications

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Differential regulation of centrosome integrity by DNA damage response proteins.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Restoration of p53 function leads to tumour regression in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

The IARC TP53 database: new online mutation analysis and recommendations to users

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

Characterization of a carboxy-terminal BRCA1 interacting protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4417661

The comet assay: a method to measure DNA damage in individual cells

15 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2014.367

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2014.367

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2014.367

Two differential pathways from double-negative to double-positive thymocytes

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25362854

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2014.367

1 reference

8 August 2017

1 reference

8 August 2017

1 reference