(Q35572443)

8 August 2017

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title

Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways (English)

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8 August 2017

Qiang Shen

1

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8 August 2017

Powel H Brown

series ordinal

2

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8 August 2017

publication date

1 January 2003

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Journal of Mammary Gland Biology and Neoplasia

8 August 2017

published in

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8 August 2017

volume

8

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8 August 2017

issue

1

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8 August 2017

page(s)

45-73

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

8 August 2017

cites work

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12 December 2020

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

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12 December 2020

Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.

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12 December 2020

Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells

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12 December 2020

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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12 December 2020

ERK7 is an autoactivated member of the MAPK family

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12 December 2020

First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial

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12 December 2020

1,25-Dihydroxyvitamin D3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20)

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12 December 2020

AP-1 blockade inhibits the growth of normal and malignant breast cells

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12 December 2020

Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review).

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12 December 2020

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

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12 December 2020

Presence of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture

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12 December 2020

Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK.

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12 December 2020

Analysis of vitamin D-receptor (VDR) and retinoid X-receptor alpha in breast cancer

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12 December 2020

Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF.

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12 December 2020

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

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12 December 2020

Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines

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12 December 2020

Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium

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12 December 2020

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

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12 December 2020

Farnesyltransferase inhibitors in breast cancer therapy

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12 December 2020

Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity

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12 December 2020

A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer

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12 December 2020

Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.

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12 December 2020

Nuclear factor-kappa B and cancer: its role in prevention and therapy

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12 December 2020

Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer

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12 December 2020

Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma.

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12 December 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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12 December 2020

The EGF receptor family as targets for cancer therapy

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12 December 2020

Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study

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12 December 2020

Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.

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12 December 2020

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

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12 December 2020

The steroid and thyroid hormone receptor superfamily

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12 December 2020

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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12 December 2020

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

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12 December 2020

Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia

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12 December 2020

MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition

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12 December 2020

Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor

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12 December 2020

Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents

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12 December 2020

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

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12 December 2020

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

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12 December 2020

Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia.

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12 December 2020

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

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12 December 2020

Hematologic malignancies: new developments and future treatments

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12 December 2020

Discovery of a novel Raf kinase inhibitor

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12 December 2020

Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor

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12 December 2020

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

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12 December 2020

Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin

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12 December 2020

Mechanisms of estrogen action

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12 December 2020

Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats

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12 December 2020

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

1 reference

12 December 2020

Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

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12 December 2020

Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment

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12 December 2020

Phase I trial of 1alpha-hydroxyvitamin d(2) in patients with hormone refractory prostate cancer

1 reference

12 December 2020

Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis

1 reference

12 December 2020

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

12 December 2020

Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity

1 reference

12 December 2020

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase

1 reference

12 December 2020

Chemopreventive efficacy of combined retinoid and tamoxifen treatment following surgical excision of a primary mammary cancer in female rats

1 reference

12 December 2020

The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation

1 reference

12 December 2020

Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.

1 reference

12 December 2020

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on breast cells: a mini review

1 reference

12 December 2020

Interaction of retinoids and tamoxifen on the inhibition of human mammary carcinoma cell proliferation

1 reference

12 December 2020

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069

1 reference

12 December 2020

Oncogenic kinase signalling

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12 December 2020

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

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12 December 2020

Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer

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12 December 2020

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

1 reference

12 December 2020

A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers

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12 December 2020

Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results

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12 December 2020

Cyclooxygenase-2: a target for the prevention and treatment of breast cancer

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12 December 2020

Sex steroids induced up-regulation of 1,25-(OH)2 vitamin D3 receptors in T 47D breast cancer cells

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12 December 2020

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

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12 December 2020

Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast

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12 December 2020

Linkage between retinoid and fatty acid receptors: implications for breast cancer prevention

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12 December 2020

Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation.

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12 December 2020

The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor.

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12 December 2020

Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.

1 reference

12 December 2020

Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.

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12 December 2020

Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway

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12 December 2020

Developing a mammary gland is a stat affair

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12 December 2020

Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages

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12 December 2020

Exisulind Cell Pathways

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12 December 2020

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

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12 December 2020

Nuclear hormone receptors and gene expression

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12 December 2020

PPARgamma, the ultimate thrifty gene

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12 December 2020

The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma

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12 December 2020

Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade

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12 December 2020

Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development

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12 December 2020

ERK1/2 mediates PDGF-BB stimulated vascular smooth muscle cell proliferation and migration on laminin-5

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12 December 2020

Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion.

1 reference

12 December 2020

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

1 reference

12 December 2020

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

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12 December 2020

Inhibition by dietary dibenzoylmethane of mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an alpha-difluoromethylornithine chemoprevention trial.

1 reference

12 December 2020

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

12 December 2020

Docetaxel and exisulind in hormone-refractory prostate cancer

1 reference

12 December 2020

Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.

1 reference

12 December 2020

Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements

1 reference

12 December 2020

Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

1 reference

12 December 2020

Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.

1 reference

12 December 2020

Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck.

1 reference

12 December 2020

MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2b

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12 December 2020

Matrix metalloproteinase gene expression

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12 December 2020

A Phase I study of LGD1069 in adults with advanced cancer

1 reference

12 December 2020

Jaks and Stats in signaling by the cytokine receptor superfamily

1 reference

12 December 2020

Clinical development of farnesyltransferase inhibitors in leukemias and myelodysplastic syndrome

1 reference

12 December 2020

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region

1 reference

12 December 2020

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1 reference

12 December 2020

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

1 reference

12 December 2020

A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.

1 reference

12 December 2020

Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

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12 December 2020

Farnesyltransferase inhibitors and anti-Ras therapy

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12 December 2020

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

12 December 2020

ZD1839 (Iressa) in non-small cell lung cancer

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12 December 2020

Hsp90 inhibitors as novel cancer chemotherapeutic agents

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12 December 2020

Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand

1 reference

12 December 2020

Mechanism of action of a dominant-negative mutant of c-Jun.

1 reference

12 December 2020

Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism

1 reference

12 December 2020

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

1 reference

12 December 2020

TNFalpha induces NFkappaB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells.

1 reference

12 December 2020

Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.

1 reference

12 December 2020

Differentiation and reversal of malignant changes in colon cancer through PPARgamma

1 reference

12 December 2020

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

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12 December 2020

Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells

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12 December 2020

The role of mitogen-activated protein (MAP) kinase in breast cancer

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12 December 2020

Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.

1 reference

12 December 2020

New insights into the role of nuclear factor-kB in cell growth regulation

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12 December 2020

Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats

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12 December 2020

Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells

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12 December 2020

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

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12 December 2020

The ras signaling pathway in mammary tumorigenesis and metastasis.

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12 December 2020

Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis

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12 December 2020

Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units

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12 December 2020

Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen

1 reference

12 December 2020

Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.

1 reference

12 December 2020

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

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12 December 2020

High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.

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12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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12 December 2020

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

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12 December 2020

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

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12 December 2020

HER-targeted tyrosine-kinase inhibitors

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12 December 2020

Phase II chemoprevention trial of oral fenretinide in patients at risk for adenocarcinoma of the prostate.

1 reference

12 December 2020

Tamoxifen in the treatment of breast cancer

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12 December 2020

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

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12 December 2020

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

1 reference

12 December 2020

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

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12 December 2020

Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells

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12 December 2020

Induction of retinoid resistance in breast cancer cells by overexpression of cJun

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12 December 2020

Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-jun

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12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Identification of cytokine-induced nuclear factor-kappaB target genes in ovarian and breast cancer cells

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12 December 2020

Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

1 reference

12 December 2020

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells

1 reference

12 December 2020

Development of anticancer drugs targeting the MAP kinase pathway

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12 December 2020

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

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12 December 2020

Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.

1 reference

12 December 2020

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

1 reference

12 December 2020

Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice

1 reference

12 December 2020

Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study

1 reference

12 December 2020

Frequency of 1,25-dihydroxyvitamin D3 receptor in human breast cancer

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12 December 2020

Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells

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12 December 2020

Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research

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12 December 2020

N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat

1 reference

12 December 2020

c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A).

1 reference

12 December 2020

Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses

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12 December 2020

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

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12 December 2020

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

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12 December 2020

A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions

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12 December 2020

Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells

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12 December 2020

Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

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12 December 2020

Chemoprevention of MNU-induced mammary tumors in the mature rat by 4-HPR and tamoxifen

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12 December 2020

Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays

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12 December 2020

Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents

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12 December 2020

Structural basis of inhibitor selectivity in MAP kinases

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12 December 2020

A novel inhibitor of nuclear factor-kappa B and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivo

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12 December 2020

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

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12 December 2020

The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines

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12 December 2020

C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.

1 reference

12 December 2020

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

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12 December 2020

Ras activation in human breast cancer

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12 December 2020

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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12 December 2020

Activation and inhibition of the AP-1 complex in human breast cancer cells

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12 December 2020

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12 December 2020

The ErbB receptor family: a therapeutic target for cancer

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12 December 2020

Experimental studies on the effects of the combined use of N-(4-hydroxyphenyl)retinamide (4-HPR) and tamoxifen (TAM) for estrogen receptor (ER)-negative breast cancer

1 reference

12 December 2020

The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway

1 reference

12 December 2020

Molecular determinants of tissue selectivity in estrogen receptor modulators

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12 December 2020

The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice.

1 reference

12 December 2020

Over-expression of bcl-xL gene in human gastric adenomas and carcinomas.

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12 December 2020

Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK

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12 December 2020

Direct control of the Forkhead transcription factor AFX by protein kinase B

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12 December 2020

Farnesyl:protein transferase inhibitors as potential agents for the management of human prostate cancer

1 reference

12 December 2020

Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer

1 reference

12 December 2020

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

1 reference

12 December 2020

Vitamin D3 receptor (VDR) expression in HC-11 mammary cells: regulation by growth-modulatory agents, differentiation, and Ha-ras transformation

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12 December 2020

Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231.

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12 December 2020

Stats: transcriptional control and biological impact

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12 December 2020

Phase I and pharmacological study of the oral farnesyltransferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours

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12 December 2020

The Royal Marsden Hospital (RMH) trial: key points and remaining questions.

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12 December 2020

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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12 December 2020

Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor

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12 December 2020

Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance

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12 December 2020

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses

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12 December 2020

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

1 reference

12 December 2020

Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation

1 reference

12 December 2020

Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway

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12 December 2020

Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer

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12 December 2020

Farnesyl transferase inhibitors--a novel therapy for breast cancer

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12 December 2020

Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines

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12 December 2020

ERK8, a new member of the mitogen-activated protein kinase family

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12 December 2020

Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancer.

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12 December 2020

Loss of Stat5a delays mammary cancer progression in a mouse model.

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12 December 2020

Stereospecific antitumor activity of radicicol oxime derivatives

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12 December 2020

Components of a new human protein kinase signal transduction pathway

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12 December 2020

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

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12 December 2020

Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands

1 reference

12 December 2020

9-Cis retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein.

1 reference

12 December 2020

Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo

1 reference

12 December 2020

Chemoprevention of cancer

1 reference

12 December 2020

The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells

1 reference

12 December 2020

Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells

1 reference

12 December 2020

Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.

1 reference

12 December 2020

XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase

1 reference

12 December 2020

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

12 December 2020

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

1 reference

12 December 2020

Inhibitors of tyrosine kinase

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12 December 2020

Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5

1 reference

12 December 2020

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death

1 reference

12 December 2020

Making decisions through Myc.

1 reference

12 December 2020

Inhibition of p38 MAP kinase as a therapeutic strategy

1 reference

12 December 2020

Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor

1 reference

12 December 2020

Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane

1 reference

12 December 2020

Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.

1 reference

12 December 2020

Prostaglandin in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells.

1 reference

12 December 2020

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone

1 reference

12 December 2020

Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.

1 reference

12 December 2020

Mitogen-activated protein kinase cascade in breast cancer

1 reference

12 December 2020

Farnesyltransferase inhibitors and myeloid malignancies: phase I evidence of Zarnestra activity in high-risk leukemias

1 reference

12 December 2020

Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

1 reference

12 December 2020

The Rel/NF-kappaB signal transduction pathway: introduction

1 reference

12 December 2020

Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

1 reference

12 December 2020

Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs).

1 reference

12 December 2020

Farnesyltransferase inhibitors as radiation sensitizers

1 reference

12 December 2020

Dose-response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis.

1 reference

12 December 2020

Expression pattern of the AP-1 family in breast cancer: association of fosB expression with a well-differentiated, receptor-positive tumor phenotype

1 reference

12 December 2020

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

1 reference

12 December 2020

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor

1 reference

12 December 2020

Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells.

1 reference

12 December 2020

Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival

1 reference

12 December 2020

PI 3-kinase: a pivotal pathway in T-cell activation?

1 reference

12 December 2020

Overexpression of extracellular-signal regulated kinases on oral squamous cell carcinoma

1 reference

12 December 2020

The vitamin D3 analog, ILX-23-7553, enhances the response to adriamycin and irradiation in MCF-7 breast tumor cells

1 reference

12 December 2020

Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

1 reference

12 December 2020

Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth

1 reference

12 December 2020

Mammary gland involution is delayed by activated Akt in transgenic mice.

1 reference

12 December 2020

Biological and clinical associations of c-jun activation in human breast cancer

1 reference

12 December 2020

Chemotherapeutic evaluation of Celecoxib, a cyclooxygenase-2 inhibitor, in a rat mammary tumor model

1 reference

12 December 2020

Fenretinide and its relation to cancer

1 reference

12 December 2020

Overexpression and overactivation of Akt in thyroid carcinoma

1 reference

12 December 2020

BAY 43-9006: early clinical data in patients with advanced solid malignancies

1 reference

12 December 2020

Epidermal growth factor receptor-targeted therapy for pancreatic cancer

1 reference

12 December 2020

The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line.

1 reference

12 December 2020

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

1 reference

12 December 2020

Cancer chemoprevention

1 reference

12 December 2020

The second generation of COX-2 inhibitors: what advantages do the newest offer?

1 reference

12 December 2020

Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells

1 reference

12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1 reference

12 December 2020

A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer

1 reference

12 December 2020

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases

1 reference

12 December 2020

Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2.

1 reference

12 December 2020

A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion.

1 reference

12 December 2020

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

12 December 2020

cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotype

1 reference

12 December 2020

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo

1 reference

12 December 2020

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

1 reference

12 December 2020

A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer

1 reference

12 December 2020

Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

1 reference

12 December 2020

ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.

1 reference

12 December 2020

COX-2 is expressed in human pulmonary, colonic, and mammary tumors.

1 reference

12 December 2020

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

12 December 2020

9-cis-Retinoic acid suppresses mammary tumorigenesis in C3(1)-simian virus 40 T antigen-transgenic mice

1 reference

12 December 2020

VX-745. Vertex Pharmaceuticals

1 reference

12 December 2020

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

1 reference

12 December 2020

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

1 reference

12 December 2020

Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats.

1 reference

12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

12 December 2020

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation

1 reference

12 December 2020

The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin

1 reference

12 December 2020

Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1 reference

12 December 2020

EGFR dependent expression of STAT3 (but not STAT1) in breast cancer

1 reference

12 December 2020

The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells

1 reference

12 December 2020

Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor.

1 reference

12 December 2020

MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines

1 reference

12 December 2020

Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer.

1 reference

12 December 2020

Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis

1 reference

12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

1 reference

12 December 2020

Peroxisome proliferator-activated receptor (PPAR) modulators: diabetes and beyond

1 reference

12 December 2020

Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells

1 reference

12 December 2020

Analysis of signaling protein kinases in human colon or colorectal carcinomas

1 reference

12 December 2020

Peroxisome proliferator-activated receptors, orphans with ligands and functions

1 reference

12 December 2020

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

12 December 2020

4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors

1 reference

12 December 2020

Regulation of Raf-Akt Cross-talk

1 reference

12 December 2020

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

1 reference

12 December 2020

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors

1 reference

12 December 2020

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

1 reference

12 December 2020

Cancer prevention science and practice

1 reference

12 December 2020

Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells

1 reference

12 December 2020

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

12 December 2020

Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells

1 reference

12 December 2020

Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer.

1 reference

12 December 2020

The mechanisms of action of PPARs

1 reference

12 December 2020

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

1 reference

12 December 2020

A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors.

1 reference

12 December 2020

Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors.

1 reference

12 December 2020

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

12 December 2020

The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women

1 reference

12 December 2020

Curcumin exerts multiple suppressive effects on human breast carcinoma cells

1 reference

12 December 2020

Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma

1 reference

12 December 2020

Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer

1 reference

12 December 2020

Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice

1 reference

12 December 2020

Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers

1 reference

12 December 2020

Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.

1 reference

12 December 2020

Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma

1 reference

12 December 2020

Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo

1 reference

12 December 2020

Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033.

1 reference

12 December 2020

The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1025783221557

1 reference

Dimensions Publication ID

8 August 2017

1024407634

0 references

1 reference