(Q35585307)

9 August 2017

title

MUC1 is a substrate for gamma-secretase (English)

1 reference

9 August 2017

Joanne Julian

1

1 reference

9 August 2017

Neeraja Dharmaraj

series ordinal

2

1 reference

9 August 2017

Daniel D Carson

series ordinal

3

1 reference

9 August 2017

publication date

1 November 2009

1 reference

Journal of Cellular Biochemistry

9 August 2017

published in

1 reference

9 August 2017

volume

108

1 reference

9 August 2017

issue

4

1 reference

9 August 2017

page(s)

802-815

1 reference

A minimal fragment of MUC1 mediates growth of cancer cells

9 August 2017

cites work

1 reference

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The MUC1 HMFG1 glycoform is a precursor to the 214D4 glycoform in the human uterine epithelial cell line, HES.

27 July 2018

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The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop

27 July 2018

1 reference

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Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells

27 July 2018

1 reference

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Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.

27 July 2018

1 reference

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Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts

27 July 2018

1 reference

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MUC1 is a novel regulator of ErbB1 receptor trafficking

27 July 2018

1 reference

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Tyrosines in the MUC1 cytoplasmic tail modulate transcription via the extracellular signal-regulated kinase 1/2 and nuclear factor-kappaB pathways

27 July 2018

1 reference

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N-Glycosylation of the MUC1 mucin in epithelial cells and secretions

27 July 2018

1 reference

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MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90

27 July 2018

1 reference

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The MUC1 SEA module is a self-cleaving domain.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line

27 July 2018

1 reference

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MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.

27 July 2018

1 reference

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TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.

27 July 2018

1 reference

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Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein

27 July 2018

1 reference

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Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

RIPped out by presenilin-dependent gamma-secretase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways

27 July 2018

1 reference

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Glutamate Receptor Subunit 3 Is Modified by Site-specific Limited Proteolysis Including Cleavage by γ-Secretase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Multiple proteases process viral antigens for presentation by MHC class I molecules to CD8(+) T lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

MUC1, the renaissance molecule

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Human MUC1 mucin: a multifaceted glycoprotein.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

MUC1: the polymorphic appearance of a human mucin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Cell-associated episialin is a complex containing two proteins derived from a common precursor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

MUC1 intra-cellular trafficking is clathrin, dynamin, and rab5 dependent.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Nicastrin functions as a gamma-secretase-substrate receptor

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Association of active gamma-secretase complex with lipid rafts.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Pseudomonas aeruginosa stimulates phosphorylation of the airway epithelial membrane glycoprotein Muc1 and activates MAP kinase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Gamma-secretase: proteasome of the membrane?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain shedding

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Gamma-secretase activity is associated with a conformational change of nicastrin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228317

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

26 September 2018

1 reference

12 December 2020

Synthesis and intracellular trafficking of Muc-1 and mucins by polarized mouse uterine epithelial cells

1 reference

12 December 2020

The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein

1 reference

12 December 2020

MEROPS: the peptidase database

1 reference

12 December 2020

Identifiers

DOI

10.1002/JCB.22292

1 reference

9 August 2017

1 reference

9 August 2017

1 reference